HEXA

Description		hexosaminidase subunit alpha
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GO Annotations	Cellular Component	Cytosol Membrane Azurophil Granule Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Protein Heterodimerization Activity N-acetyl-beta-D-galactosaminidase Activity
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Chondroitin Sulfate Catabolic Process Hyaluronan Catabolic Process Keratan Sulfate Catabolic Process
Pathways		Glycosphingolipid metabolism Keratan sulfate degradation CS/DS degradation Hyaluronan uptake and degradation Defective HEXA causes GM2G1
Drugs
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS
Interacting Genes		2 interacting genes: GM2A USP22
Entrez ID		3073
HPRD ID		06040
Ensembl ID		ENSG00000213614
Uniprot IDs		A0A0S2Z3W3 B4DVA7 H3BP20 P06865
PDB IDs		1QBC 2GJX 2GK1
Enriched GO Terms of Interacting Partners?
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