USP22 and CD274

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		USP22	CD274
Description		ubiquitin specific peptidase 22	CD274 molecule
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleoplasm SAGA-type Complex	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Nuclear Receptor Coactivator Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Embryo Development Ending In Birth Or Egg Hatching Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle	Adaptive Immune Response Positive Regulation Of Tolerance Induction To Tumor Cell Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Response To Cytokine Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Toxin Transport Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways		HATs acetylate histones Ub-specific processing proteases	PD-1 signaling
Drugs			Atezolizumab Durvalumab Avelumab Envafolimab Cosibelimab AUNP-12 CA-170 anti-OX40 antibody BMS 986178
Diseases
GWAS		Body mass index ( 26426971) Mosquito bite size ( 28199695)	Blood protein levels ( 30072576)
Interacting Genes		17 interacting genes: AASDHPPT ATXN7 ATXN7L3 BAG4 CD274 H2AC20 H2BC21 HEXA MRPL10 MRPL44 MTUS2 MYC PSME1 PTGS2 RCAN1 SCFD1 UBC	4 interacting genes: CD80 COPS5 PDCD1 USP22
Entrez ID		23326	29126
HPRD ID		19411	05655
Ensembl ID		ENSG00000124422	ENSG00000120217
Uniprot IDs		Q9UPT9	Q0GN75 Q9NZQ7
PDB IDs			3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5GGT 5GRJ 5IUS 5J89 5J8O 5JDR 5JDS 5N2D 5N2F 5NIU 5O45 5O4Y 5X8L 5X8M 5XJ4 5XXY 6NM7 6NM8 6NNV 6NOJ 6NOS 6NP9 6PV9 6R3K 6RPG
Enriched GO Terms of Interacting Partners?
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