USP22 and PTGS2

Data Source:
BioGRID (enzymatic study)

		USP22	PTGS2
Description		ubiquitin specific peptidase 22	prostaglandin-endoperoxide synthase 2
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleoplasm SAGA-type Complex	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Nuclear Receptor Coactivator Activity	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Enzyme Binding Heme Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Embryo Development Ending In Birth Or Egg Hatching Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle	Prostaglandin Biosynthetic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Positive Regulation Of Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Cyclooxygenase Pathway Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Hypoxia Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response
Pathways		HATs acetylate histones Ub-specific processing proteases	Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs			Dihomo-gamma-linolenic acid Icosapent Aminosalicylic acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Firocoxib Morniflumate Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Dipyrithione Bryostatin 1 Alclofenac Bufexamac Bendazac Acemetacin Fish oil Medical Cannabis Nabiximols
Diseases			Esophageal cancer Cholangiocarcinoma Penile cancer
GWAS		Body mass index ( 26426971) Mosquito bite size ( 28199695)	Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)
Interacting Genes		17 interacting genes: AASDHPPT ATXN7 ATXN7L3 BAG4 CD274 H2AC20 H2BC21 HEXA MRPL10 MRPL44 MTUS2 MYC PSME1 PTGS2 RCAN1 SCFD1 UBC	13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22
Entrez ID		23326	5743
HPRD ID		19411	02599
Ensembl ID		ENSG00000124422	ENSG00000073756
Uniprot IDs		Q9UPT9	P35354
PDB IDs			1V0X 5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR
Enriched GO Terms of Interacting Partners?
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