USP22 and HEXA

Data Source:
BioGRID (two hybrid)

		USP22	HEXA
Description		ubiquitin specific peptidase 22	hexosaminidase subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleoplasm SAGA-type Complex	Cytosol Membrane Azurophil Granule Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Nuclear Receptor Coactivator Activity	Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Protein Heterodimerization Activity N-acetyl-beta-D-galactosaminidase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Embryo Development Ending In Birth Or Egg Hatching Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Chondroitin Sulfate Catabolic Process Hyaluronan Catabolic Process Keratan Sulfate Catabolic Process
Pathways		HATs acetylate histones Ub-specific processing proteases	Glycosphingolipid metabolism Keratan sulfate degradation CS/DS degradation Hyaluronan uptake and degradation Defective HEXA causes GM2G1
Drugs
Diseases			GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Body mass index ( 26426971) Mosquito bite size ( 28199695)
Interacting Genes		17 interacting genes: AASDHPPT ATXN7 ATXN7L3 BAG4 CD274 H2AC20 H2BC21 HEXA MRPL10 MRPL44 MTUS2 MYC PSME1 PTGS2 RCAN1 SCFD1 UBC	2 interacting genes: GM2A USP22
Entrez ID		23326	3073
HPRD ID		19411	06040
Ensembl ID		ENSG00000124422	ENSG00000213614
Uniprot IDs		Q9UPT9	A0A0S2Z3W3 B4DVA7 H3BP20 P06865
PDB IDs			1QBC 2GJX 2GK1
Enriched GO Terms of Interacting Partners?
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