HSD17B10 and KDM6A

Data Source:
BioGRID (affinity chromatography technology)

		HSD17B10	KDM6A
Description		hydroxysteroid 17-beta dehydrogenase 10	lysine demethylase 6A
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	Isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing	Chromatin Remodeling Heart Development Regulation Of Gene Expression Histone H3-K4 Methylation Histone H3-K27 Demethylation
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion	HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases		2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		32 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PRKN PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1	11 interacting genes: GSC2 H3-4 H3C1 H3C14 MEOX2 MTDH NKX2-5 SMAD9 SRF TBX5 TLE1
Entrez ID		3028	7403
HPRD ID		02223	02131
Ensembl ID		ENSG00000072506	ENSG00000147050
Uniprot IDs		A0A0S2Z410 Q99714	A0A087X0R0 A0A6Q8PFK0 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3 Q86TD1
PDB IDs		1F67 1SO8 1U7T 2O23	3AVR 3AVS 6FUK 6FUL
Enriched GO Terms of Interacting Partners?
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