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KDM6A and NKX2-5
Data Source:
BioGRID
(two hybrid)
KDM6A
NKX2-5
Description
lysine demethylase 6A
NK2 homeobox 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Histone Methyltransferase Complex
MLL3/4 Complex
Chromatin
Nucleus
Transcription Regulator Complex
Protein-containing Complex
Protein-DNA Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Protein Binding
Chromatin DNA Binding
Metal Ion Binding
Dioxygenase Activity
Histone Demethylase Activity (H3-K27 Specific)
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Chromatin Remodeling
Heart Development
Regulation Of Gene Expression
Histone H3-K4 Methylation
Histone H3-K27 Demethylation
Negative Regulation Of Transcription By RNA Polymerase II
Vasculogenesis
Heart Looping
Heart Morphogenesis
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Aortic Valve Morphogenesis
Right Ventricular Cardiac Muscle Tissue Morphogenesis
Atrial Cardiac Muscle Tissue Development
Septum Secundum Development
Regulation Of Transcription By RNA Polymerase II
Adult Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Transcription Via Serum Response Element Binding
Positive Regulation Of Sodium Ion Transport
Negative Regulation Of Myotube Differentiation
Hemopoiesis
Cell Differentiation
Thyroid Gland Development
Embryonic Heart Tube Development
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Heart Contraction
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Spleen Development
Positive Regulation Of Cardioblast Differentiation
Cardiac Muscle Cell Differentiation
Cardiac Muscle Tissue Morphogenesis
Cardiac Muscle Cell Development
Atrial Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Development
Regulation Of Cardiac Muscle Contraction
Pharyngeal System Development
Cardiac Muscle Contraction
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Cardiac Conduction
Pathways
HDMs demethylate histones
Activation of anterior HOX genes in hindbrain development during early embryogenesis
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Physiological factors
Drugs
Diseases
Atrial septal defect
Tetralogy of Fallot
Congenital nongoitrous hypothyroidism (CHNG)
GWAS
Atrial fibrillation (
30061737
29892015
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Heart rate (
23583979
)
Infantile hypertrophic pyloric stenosis (
22306654
)
Ischemic stroke (cardioembolic) (
29531354
)
PR interval (
30046033
32439900
20062060
)
Resting heart rate (
27798624
)
Stroke (
26089329
)
TPE interval (resting) (
32386560
)
Interacting Genes
11 interacting genes:
GSC2
H3-4
H3C1
H3C14
MEOX2
MTDH
NKX2-5
SMAD9
SRF
TBX5
TLE1
18 interacting genes:
CAMTA2
CSNK2A1
FBXO25
FOXH1
GATA4
HDAC1
HIPK1
HIPK2
JARID2
KDM6A
KRTAP8-1
RBPMS
SHOX
SRF
TBX2
TBX5
TLE1
TRIP10
Entrez ID
7403
1482
HPRD ID
02131
02787
Ensembl ID
ENSG00000147050
ENSG00000183072
Uniprot IDs
A0A087X0R0
A0A6Q8PFK0
B4E0L8
B7ZKN1
B7ZKN5
B7ZKN6
E1U0S6
F5H5V6
F5H6S1
F8W8R6
O15550
Q59HG3
Q86TD1
A0A0S2Z383
A0A0S2Z3K2
E5RH49
P52952
PDB IDs
3AVR
3AVS
6FUK
6FUL
3RKQ
4S0H
6WC2
6WC5
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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