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KDM6A and SMAD9
Data Source:
HPRD
(two hybrid)
KDM6A
SMAD9
Description
lysine demethylase 6A
SMAD family member 9
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Histone Methyltransferase Complex
MLL3/4 Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Protein Binding
Chromatin DNA Binding
Metal Ion Binding
Dioxygenase Activity
Histone Demethylase Activity (H3-K27 Specific)
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
I-SMAD Binding
Biological Process
Chromatin Remodeling
Heart Development
Regulation Of Gene Expression
Histone H3-K4 Methylation
Histone H3-K27 Demethylation
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Cell Differentiation
BMP Signaling Pathway
SMAD Protein Signal Transduction
Cellular Response To BMP Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways
HDMs demethylate histones
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Signaling by BMP
Drugs
Diseases
GWAS
Coronary artery disease (
29212778
)
Heel bone mineral density (
30598549
28869591
)
Perioperative myocardial infarction in coronary artery bypass surgery (
25948407
)
Spontaneous preterm birth (preterm birth) (
25599974
)
Total body bone mineral density (
29304378
)
Interacting Genes
11 interacting genes:
GSC2
H3-4
H3C1
H3C14
MEOX2
MTDH
NKX2-5
SMAD9
SRF
TBX5
TLE1
117 interacting genes:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MACO1
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS1
RANBP9
RFX1
RMND5A
RNF123
RRBP1
RUBCN
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TOB1
TRIM29
TRIP12
TTC37
TWNK
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
Entrez ID
7403
4093
HPRD ID
02131
04484
Ensembl ID
ENSG00000147050
ENSG00000120693
Uniprot IDs
A0A087X0R0
A0A6Q8PFK0
B4E0L8
B7ZKN1
B7ZKN5
B7ZKN6
E1U0S6
F5H5V6
F5H6S1
F8W8R6
O15550
Q59HG3
Q86TD1
A0A024RDR3
O15198
PDB IDs
3AVR
3AVS
6FUK
6FUL
6FZT
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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