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H2BC3 and DYRK1A
Data Source:
BioGRID
(enzymatic study)
H2BC3
DYRK1A
Description
H2B clustered histone 3
dual specificity tyrosine phosphorylation regulated kinase 1A
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Cytoskeleton
Nuclear Speck
Axon
Dendrite
Ribonucleoprotein Complex
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein Self-association
Tau Protein Binding
Tau-protein Kinase Activity
Biological Process
Nucleosome Assembly
Protein Ubiquitination
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Protein Phosphorylation
Nervous System Development
Circadian Rhythm
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Microtubule Polymerization
Positive Regulation Of RNA Splicing
Amyloid-beta Formation
Peptidyl-serine Autophosphorylation
Peptidyl-tyrosine Autophosphorylation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Negative Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Protein Deacetylation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
G0 and Early G1
Drugs
N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Fostamatinib
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
HIV-1 replication (
21364930
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolic syndrome (
20694148
)
Neutrophil count (
32888494
)
Parkinson's disease (
32201043
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Stroke (
30383316
)
White blood cell count (
32888494
)
Interacting Genes
25 interacting genes:
AKT1
APP
CDK1
CDK2
CREBBP
DYRK1A
EID1
EP300
ERCC6
FANCD2
H2AC4
KAT2B
MYB
PALB2
PSMD4
RHBDD2
RNF20
RNF8
RPS6KA5
UBR7
UHRF1
USP16
USP36
USP43
USP51
33 interacting genes:
-
AMPH
APP
CCNL2
CLASRP
CREB1
CREBBP
EIF2B5
FOXO1
GLI1
H2BC3
H3C1
H4C1
ID2
KPRP
LATS2
LIN52
MAPT
PEA15
PHYHIP
PRKN
RB1
RBL1
RNF169
SF3B1
SNCA
SRSF1
SRSF4
SRSF5
TROAP
YWHAB
YWHAE
YWHAG
Entrez ID
3018
1859
HPRD ID
07536
09018
Ensembl ID
ENSG00000276410
ENSG00000157540
Uniprot IDs
P33778
A0A2R8Y6I6
Q13627
PDB IDs
3X1S
3X1U
2VX3
2WO6
3ANQ
3ANR
4AZE
4MQ1
4MQ2
4NCT
4YLJ
4YLK
4YLL
4YU2
5A3X
5A4E
5A4L
5A4Q
5A4T
5A54
5AIK
6A1F
6A1G
6EIF
6EIJ
6EIL
6EIP
6EIQ
6EIR
6EIS
6EIV
6EJ4
6QU2
6S11
6S14
6S17
6S1B
6S1H
6S1I
6S1J
6T6A
6UIP
6UWY
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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