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DYRK1A and H3C1
Data Source:
BioGRID
(enzymatic study)
DYRK1A
H3C1
Description
dual specificity tyrosine phosphorylation regulated kinase 1A
H3 clustered histone 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytoskeleton
Nuclear Speck
Axon
Dendrite
Ribonucleoprotein Complex
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein-containing Complex
Extracellular Exosome
Molecular Function
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein Self-association
Tau Protein Binding
Tau-protein Kinase Activity
DNA Binding
Protein Binding
Cadherin Binding
Protein Heterodimerization Activity
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Protein Phosphorylation
Nervous System Development
Circadian Rhythm
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Microtubule Polymerization
Positive Regulation Of RNA Splicing
Amyloid-beta Formation
Peptidyl-serine Autophosphorylation
Peptidyl-tyrosine Autophosphorylation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Negative Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Protein Deacetylation
RDNA Heterochromatin Assembly
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
Blood Coagulation
Telomere Organization
Interleukin-7-mediated Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Silencing By MiRNA
Regulation Of Gene Silencing
Pathways
G0 and Early G1
Interleukin-7 signaling
Interleukin-7 signaling
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
Chromatin modifying enzymes
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production
Drugs
N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Fostamatinib
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
HIV-1 replication (
21364930
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolic syndrome (
20694148
)
Neutrophil count (
32888494
)
Parkinson's disease (
32201043
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Stroke (
30383316
)
White blood cell count (
32888494
)
Interacting Genes
33 interacting genes:
-
AMPH
APP
CCNL2
CLASRP
CREB1
CREBBP
EIF2B5
FOXO1
GLI1
H2BC3
H3C1
H4C1
ID2
KPRP
LATS2
LIN52
MAPT
PEA15
PHYHIP
PRKN
RB1
RBL1
RNF169
SF3B1
SNCA
SRSF1
SRSF4
SRSF5
TROAP
YWHAB
YWHAE
YWHAG
156 interacting genes:
AIRE
AKT2
ANP32A
ANP32B
ASH1L
ASH2L
ATXN1
AURKA
AURKB
AURKC
BCAS3
CARM1
CBX1
CBX3
CENPM
CENPT
CENPW
CHD3
CHD4
COPS2
CREBBP
CTCFL
CUL4A
DCAF1
DDB1
DNAJC9
DNMT1
DNMT3A
DNMT3B
DPF2
DYRK1A
EED
EHMT1
EHMT2
EID1
EP300
ERCC6
ESCO1
EZH2
FANCD2
FBLIM1
GATAD2A
GATAD2B
GLYR1
GRIP1
H2AC20
H4C14
HASPIN
HAT1
HDAC1
HDAC2
HDAC3
HDAC5
HDAC6
HDAC8
HDGFL3
HNF1B
HNRNPA1
HNRNPAB
HPF1
HSPA8
ING4
JMJD6
KAT14
KAT2B
KAT5
KAT6A
KAT7
KDM1A
KDM2B
KDM4A
KDM4C
KDM6A
KDM6B
KMT2A
KMT2B
KMT2C
L3MBTL2
MAD2L1
MBD5
MLLT3
MPHOSPH8
MSL3
MYB
NAP1L1
NASP
NCOR1
NR1H4
NR3C1
NSD1
NSD2
NSD3
PAF1
PAK1
PALB2
PARP1
PARP10
PARP2
PAXIP1
PBRM1
PHF1
PHF19
PHF20
PHF8
PIKFYVE
PPM1D
PPP1CA
PPP1CB
PRDM2
PRKCA
PRKCB
PRMT1
PRMT5
PRMT7
PWWP3B
RAD51B
RAG1
RBBP4
RBBP7
RCC1
RPS6KA3
SETD1A
SETD1B
SETD2
SETD7
SETDB1
SIRT1
SIRT2
SIRT3
SIRT7
SMARCA2
SMARCA4
SMARCA5
SUV39H1
TAF15
TAF1A
TAF1B
THAP7
TLE3
TRIM33
TSSK6
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E3
UHRF1
UHRF2
WDR5
WWC1
YEATS4
YWHAB
YWHAG
YWHAZ
ZMYND8
Entrez ID
1859
8350
HPRD ID
09018
04155
Ensembl ID
ENSG00000157540
ENSG00000275714
Uniprot IDs
A0A2R8Y6I6
Q13627
P68431
PDB IDs
2VX3
2WO6
3ANQ
3ANR
4AZE
4MQ1
4MQ2
4NCT
4YLJ
4YLK
4YLL
4YU2
5A3X
5A4E
5A4L
5A4Q
5A4T
5A54
5AIK
6A1F
6A1G
6EIF
6EIJ
6EIL
6EIP
6EIQ
6EIR
6EIS
6EIV
6EJ4
6QU2
6S11
6S14
6S17
6S1B
6S1H
6S1I
6S1J
6T6A
6UIP
6UWY
1CS9
1CT6
1O9S
1Q3L
2B2T
2B2U
2B2V
2B2W
2C1J
2C1N
2CO0
2CV5
2FSA
2KWJ
2KWK
2L75
2LBM
2LGG
2M0O
2NDF
2NDG
2OQ6
2OT7
2OX0
2RI7
2RR4
2UXN
2V85
2V89
2VNF
2VPG
2X0L
3A1B
3AFA
3AVR
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3B95
3FDT
3KMT
3KQI
3LQI
3LQJ
3MP1
3O34
3O35
3O37
3QJ6
3RIG
3RIY
3SOU
3SOW
3U31
3U3D
3U4S
3U5N
3U5O
3U5P
3UEE
3UEF
3UIG
3UII
3UIK
3V43
3W96
3W97
3W98
3W99
3WA9
3WAA
3WKJ
3X1S
3X1T
3X1U
3X1V
3ZG6
3ZVY
4A0J
4A0N
4A7J
4BD3
4C1Q
4F4U
4F56
4FWF
4HON
4I51
4L7X
4LK9
4LKA
4LLB
4LXL
4N4H
4QBQ
4QBR
4QBS
4TN7
4U68
4UP0
4UY4
4X3K
4Y6L
4YHP
4YHZ
4YM5
4YM6
4Z0R
4Z2M
5AV5
5AV6
5AV8
5AV9
5AVB
5AVC
5B24
5B2I
5B2J
5B31
5C11
5C13
5C3I
5CPI
5CPJ
5CPK
5D6Y
5DAH
5FB0
5FB1
5FFV
5GH9
5GSE
5GSU
5GT0
5GT3
5GTC
5H6Q
5H6R
5HJB
5HJC
5HJD
5HYN
5IQL
5J3V
5J9S
5JHN
5JIN
5JIY
5JJ0
5JRG
5KJH
5KJI
5KKL
5LUG
5M5G
5MR8
5NNC
5NND
5OY3
5SVX
5SVY
5SZB
5SZC
5T0K
5T0M
5T1G
5T1I
5T8R
5TBN
5TDR
5TDW
5U2J
5V21
5V22
5VA6
5VAB
5VGE
5VNB
5WFC
5WLE
5WVO
5WXG
5WXH
5WYI
5X60
5XF3
5XF4
5XF5
5XFQ
5XFR
5XNV
5XTZ
5Y0C
5Y0D
5Y20
5Y2F
5Z23
5Z30
6AXJ
6AZE
6BHD
6BHE
6BHG
6BHH
6BHI
6D07
6D08
6E83
6E86
6F6D
6HKT
6HTS
6IEU
6IIS
6IIT
6IPU
6IQ4
6JOU
6JR0
6JR1
6JXD
6K1I
6K1J
6K1K
6KE9
6KVD
6L49
6L4A
6L9H
6LA8
6LA9
6LE9
6M3V
6M44
6M4D
6M4G
6M4H
6MIL
6MIM
6MIN
6MIO
6MIQ
6R8Y
6R8Z
6R90
6R91
6R92
6R93
6R94
6T90
6T93
6UPK
6UPL
6USJ
6V2H
6V3N
6V41
6V92
6VIL
6WAV
6WW4
6YIF
6YIH
6YOV
7C0M
7CCQ
7CCR
Enriched GO Terms of Interacting Partners
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