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H2BC3 and RHBDD2
Data Source:
BioGRID
(two hybrid)
H2BC3
RHBDD2
Description
H2B clustered histone 3
rhomboid domain containing 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Cytosol
Golgi Membrane
Hrd1p Ubiquitin Ligase ERAD-L Complex
Nucleoplasm
Golgi Apparatus
Integral Component Of Endoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Serine-type Endopeptidase Activity
Misfolded Protein Binding
Ubiquitin-specific Protease Binding
Biological Process
Nucleosome Assembly
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Response to cognitive-behavioural therapy in major depressive disorder (
31123309
)
Sum eosinophil basophil counts (
27863252
)
Interacting Genes
25 interacting genes:
AKT1
APP
CDK1
CDK2
CREBBP
DYRK1A
EID1
EP300
ERCC6
FANCD2
H2AC4
KAT2B
MYB
PALB2
PSMD4
RHBDD2
RNF20
RNF8
RPS6KA5
UBR7
UHRF1
USP16
USP36
USP43
USP51
58 interacting genes:
ABHD16A
ACSF2
ADORA2A
BCL2L1
BCL2L2
CCR9
CHRM4
CIAO2A
CIDEB
COL8A1
COMT
DIABLO
DRD2
DYNC1H1
ERBB2
FKBP8
FMO4
GAL3ST3
GCSH
GDF5-AS1
H2BC3
H4C7
IFI27L1
IL32
LETMD1
LIG4
MAOB
MFSD14C
MICOS13
MIEF2
MLX
MMRN2
MPC2
MRM1
MRPL35
MTERF3
MYG1
NAALAD2
NCBP2AS2
NFU1
NRM
PBX3
PTAFR
ROMO1
RSAD2
SCGB3A1
SDHD
SLC25A2
SLC25A3
SNPH
SYT16
TEX44
THBD
TIMM17B
TPRG1
TSR1
TUFM
USP30
Entrez ID
3018
57414
HPRD ID
07536
11492
Ensembl ID
ENSG00000276410
ENSG00000005486
Uniprot IDs
P33778
Q6NTF9
PDB IDs
3X1S
3X1U
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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