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H2BC3
Description
H2B clustered histone 3
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Cytosol
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Nucleosome Assembly
Protein Ubiquitination
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Interacting Genes
25 interacting genes:
AKT1
APP
CDK1
CDK2
CREBBP
DYRK1A
EID1
EP300
ERCC6
FANCD2
H2AC4
KAT2B
MYB
PALB2
PSMD4
RHBDD2
RNF20
RNF8
RPS6KA5
UBR7
UHRF1
USP16
USP36
USP43
USP51
Entrez ID
3018
HPRD ID
07536
Ensembl ID
ENSG00000276410
Uniprot IDs
P33778
PDB IDs
3X1S
3X1U
Enriched GO Terms of Interacting Partners
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