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H2BC3 and PALB2
Data Source:
BioGRID
(pull down)
H2BC3
PALB2
Description
H2B clustered histone 3
partner and localizer of BRCA2
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Cytosol
Nucleoplasm
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
DNA Binding
Protein Binding
Biological Process
Nucleosome Assembly
Protein Ubiquitination
Double-strand Break Repair Via Homologous Recombination
Somitogenesis
Inner Cell Mass Cell Proliferation
Mesoderm Development
Animal Organ Morphogenesis
Multicellular Organism Growth
Post-anal Tail Morphogenesis
Negative Regulation Of Apoptotic Process
Embryonic Organ Development
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Drugs
Diseases
Fanconi anemia
GWAS
Bipolar disorder (
17554300
)
Interacting Genes
25 interacting genes:
AKT1
APP
CDK1
CDK2
CREBBP
DYRK1A
EID1
EP300
ERCC6
FANCD2
H2AC4
KAT2B
MYB
PALB2
PSMD4
RHBDD2
RNF20
RNF8
RPS6KA5
UBR7
UHRF1
USP16
USP36
USP43
USP51
32 interacting genes:
BCAS3
BRCA2
CASZ1
CCL5
CST6
DIRAS3
ERRFI1
GREB1
H2BC3
H3C1
H4C1
HNRNPC
IL13RA2
IL24
KEAP1
KLK6
LRATD2
LYPD3
MRC2
NAT2
PDS5B
PRDM14
RAD51
RAD51AP1
RAD51C
RHOBTB2
RNF168
SERPINB5
SNAI1
THRSP
USP2
XRCC3
Entrez ID
3018
79728
HPRD ID
07536
07966
Ensembl ID
ENSG00000276410
ENSG00000083093
Uniprot IDs
P33778
H3BN63
Q86YC2
PDB IDs
3X1S
3X1U
2W18
3EU7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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