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DYRK1A and PRKN
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
DYRK1A
PRKN
Description
dual specificity tyrosine phosphorylation regulated kinase 1A
parkin RBR E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytoskeleton
Nuclear Speck
Axon
Dendrite
Ribonucleoprotein Complex
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Aggresome
Nuclear Speck
SCF Ubiquitin Ligase Complex
Neuron Projection
Perinuclear Region Of Cytoplasm
Lewy Body
Presynapse
Mitochondrion-derived Vesicle
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein Self-association
Tau Protein Binding
Tau-protein Kinase Activity
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Tubulin Binding
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Phospholipase Binding
Protein-containing Complex Binding
Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Protein Phosphorylation
Nervous System Development
Circadian Rhythm
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Microtubule Polymerization
Positive Regulation Of RNA Splicing
Amyloid-beta Formation
Peptidyl-serine Autophosphorylation
Peptidyl-tyrosine Autophosphorylation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Negative Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Protein Deacetylation
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Mitochondrial Fission
Autophagy Of Mitochondrion
Mitophagy
Negative Regulation Of Protein Phosphorylation
Startle Response
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Response To Oxidative Stress
Mitochondrion Organization
Central Nervous System Development
Learning
Adult Locomotory Behavior
Proteasomal Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Free Ubiquitin Chain Polymerization
Regulation Of Dopamine Secretion
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Protein Destabilization
Positive Regulation Of Protein Binding
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
ERAD Pathway
Regulation Of Dopamine Metabolic Process
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Cellular Protein Catabolic Process
Cellular Protein Metabolic Process
Protein K27-linked Ubiquitination
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Protein Stabilization
Positive Regulation Of Neurotransmitter Uptake
Dopamine Uptake Involved In Synaptic Transmission
Protein Autoubiquitination
Regulation Of Mitochondrial Membrane Potential
Zinc Ion Homeostasis
Negative Regulation Of Cell Death
Regulation Of Canonical Wnt Signaling Pathway
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Manganese Ion
Protein K6-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Response To Toxic Substance
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Mitochondrion To Lysosome Transport
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Neuron Death
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Primary Amine Oxidase Activity
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Oxidative Stress-induced Cell Death
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Dendrite Extension
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Localization To Membrane
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
G0 and Early G1
PINK1-PRKN Mediated Mitophagy
Josephin domain DUBs
Aggrephagy
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Fostamatinib
Diseases
Parkinson's disease (PD)
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
HIV-1 replication (
21364930
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolic syndrome (
20694148
)
Neutrophil count (
32888494
)
Parkinson's disease (
32201043
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Stroke (
30383316
)
White blood cell count (
32888494
)
Interacting Genes
33 interacting genes:
-
AMPH
APP
CCNL2
CLASRP
CREB1
CREBBP
EIF2B5
FOXO1
GLI1
H2BC3
H3C1
H4C1
ID2
KPRP
LATS2
LIN52
MAPT
PEA15
PHYHIP
PRKN
RB1
RBL1
RNF169
SF3B1
SNCA
SRSF1
SRSF4
SRSF5
TROAP
YWHAB
YWHAE
YWHAG
115 interacting genes:
ADRM1
AIMP2
ARRB1
ARRB2
ATXN3
BAG5
BCL2L1
CASK
CASP1
CASP8
CCNB1
CCND1
CDC34
CDK5
CDKN1A
CHPF
COMMD1
CRX
CUL1
DLG1
DLX2
DNM1L
DYRK1A
EPS15
FAF1
FBP1
FBXO7
FBXW7
GPR37
GRIN2B
HDAC6
HEXD
HSD17B10
IKBKG
MDM2
MEOX1
MEOX2
MFN1
MFN2
NDUFA4L2
NEK2
PAFAH1B2
PDCD2
PICK1
PKM
PLK1
PRKAA2
PSMA1
PSMA7
PSMC1
PSMC2
PSMC5
PSMD4
PTPN5
PTTG1
RAB7A
RAC1
RAD1
RAD23A
RANBP2
RBCK1
REL
RGS2
RGS3
RHOT2
SEPTIN4
SEPTIN5
SIM2
SNCA
SNCAIP
STUB1
SUMO1
SYT11
TCF4
TENT5C
TOMM40
TOMM70
TP53
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2O
UBE2R2
UBE2S
UBE2T
UBE2V1
UBE2Z
UCHL1
USP30
VDAC1
YWHAH
ZNF746
Entrez ID
1859
5071
HPRD ID
09018
03967
Ensembl ID
ENSG00000157540
ENSG00000185345
Uniprot IDs
A0A2R8Y6I6
Q13627
O60260
X5DR79
PDB IDs
2VX3
2WO6
3ANQ
3ANR
4AZE
4MQ1
4MQ2
4NCT
4YLJ
4YLK
4YLL
4YU2
5A3X
5A4E
5A4L
5A4Q
5A4T
5A54
5AIK
6A1F
6A1G
6EIF
6EIJ
6EIL
6EIP
6EIQ
6EIR
6EIS
6EIV
6EJ4
6QU2
6S11
6S14
6S17
6S1B
6S1H
6S1I
6S1J
6T6A
6UIP
6UWY
1IYF
2JMO
4BM9
4I1F
4I1H
5C1Z
5C23
5C9V
5N2W
5N38
5TR5
6GLC
6HUE
6N13
Enriched GO Terms of Interacting Partners
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