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DYRK1A and GLI1
Data Source:
HPRD
(in vitro, in vivo)
DYRK1A
GLI1
Description
dual specificity tyrosine phosphorylation regulated kinase 1A
GLI family zinc finger 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytoskeleton
Nuclear Speck
Axon
Dendrite
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Axoneme
Ciliary Tip
Ciliary Base
Molecular Function
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein Self-association
Tau Protein Binding
Tau-protein Kinase Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Binding
Microtubule Binding
Metal Ion Binding
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Protein Phosphorylation
Nervous System Development
Circadian Rhythm
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Microtubule Polymerization
Positive Regulation Of RNA Splicing
Amyloid-beta Formation
Peptidyl-serine Autophosphorylation
Peptidyl-tyrosine Autophosphorylation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Negative Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Protein Deacetylation
Osteoblast Differentiation
Regulation Of Transcription By RNA Polymerase II
Smoothened Signaling Pathway
Spermatogenesis
Ventral Midline Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Smoothened Signaling Pathway
Response To Wounding
Epidermal Cell Differentiation
Dorsal/ventral Pattern Formation
Proximal/distal Pattern Formation
Cerebellar Cortex Morphogenesis
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Pituitary Gland Development
Lung Development
Prostate Gland Development
Regulation Of Osteoblast Differentiation
Positive Regulation Of DNA Replication
Positive Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Morphogenesis
Notochord Regression
Positive Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Liver Regeneration
Positive Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Hepatocyte Proliferation
Pathways
G0 and Early G1
Degradation of GLI1 by the proteasome
Degradation of GLI1 by the proteasome
Hedgehog 'off' state
Hedgehog 'on' state
GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Fostamatinib
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
HIV-1 replication (
21364930
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolic syndrome (
20694148
)
Neutrophil count (
32888494
)
Parkinson's disease (
32201043
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Stroke (
30383316
)
White blood cell count (
32888494
)
Interacting Genes
33 interacting genes:
-
AMPH
APP
CCNL2
CLASRP
CREB1
CREBBP
EIF2B5
FOXO1
GLI1
H2BC3
H3C1
H4C1
ID2
KPRP
LATS2
LIN52
MAPT
PEA15
PHYHIP
PRKN
RB1
RBL1
RNF169
SF3B1
SNCA
SRSF1
SRSF4
SRSF5
TROAP
YWHAB
YWHAE
YWHAG
22 interacting genes:
AQP1
CATSPER1
CRYBA4
DYRK1A
FEM1B
GCC1
IKBKB
PIN1
PRKAA2
PRKACA
PRMT1
PRMT5
RAI1
STK36
SUFU
TAF9
TRIM42
USP48
WDR77
XBP1
ZIC1
ZIC2
Entrez ID
1859
2735
HPRD ID
09018
01311
Ensembl ID
ENSG00000157540
ENSG00000111087
Uniprot IDs
A0A2R8Y6I6
Q13627
B4DNF7
P08151
PDB IDs
2VX3
2WO6
3ANQ
3ANR
4AZE
4MQ1
4MQ2
4NCT
4YLJ
4YLK
4YLL
4YU2
5A3X
5A4E
5A4L
5A4Q
5A4T
5A54
5AIK
6A1F
6A1G
6EIF
6EIJ
6EIL
6EIP
6EIQ
6EIR
6EIS
6EIV
6EJ4
6QU2
6S11
6S14
6S17
6S1B
6S1H
6S1I
6S1J
6T6A
6UIP
6UWY
2GLI
4BLB
4KMD
5OM0
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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