LMCD1 and FBXO25

Data Source:
BioGRID (enzymatic study)

		LMCD1	FBXO25
Description		LIM and cysteine rich domains 1	F-box protein 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cardiac Muscle Hypertrophy Cellular Protein Metabolic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade	Protein Ubiquitination
Pathways		Surfactant metabolism
Drugs
Diseases
GWAS		Brain volume in infants (intracranial brain volume) ( 28763065) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Low high density lipoprotein cholesterol levels ( 26879886) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Platelet count ( 32888494) Plateletcrit ( 32888494) Rumination (response to stress) ( 30886212) Uterine fibroid number (single vs multiple) ( 30196971)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		9 interacting genes: APP FBXO25 IKBKG NKX3-1 PRKAG3 RABIF TEKT4 TRIM55 TRIM63	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		29995	26260
HPRD ID		06891	16439
Ensembl ID		ENSG00000071282	ENSG00000147364
Uniprot IDs		B4DEY6 B7Z6R5 H7C3D2 Q9NZU5	A0A024QZ88 Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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