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FN1 and GRB2
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
FN1
GRB2
Description
fibronectin 1
growth factor receptor bound protein 2
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endosome
Golgi Apparatus
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Vesicle Membrane
Extracellular Exosome
Grb2-EGFR Complex
Molecular Function
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Protein C-terminus Binding
Heparin Binding
Peptidase Activator Activity
Enzyme Binding
Identical Protein Binding
Proteoglycan Binding
Chaperone Binding
Disordered Domain Specific Binding
Phosphotyrosine Residue Binding
RNA Binding
Epidermal Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Insulin Receptor Substrate Binding
Protein-containing Complex Binding
Ephrin Receptor Binding
Biological Process
Angiogenesis
Regulation Of Protein Phosphorylation
Platelet Degranulation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptide Cross-linking
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Leukocyte Migration
Biological Process Involved In Interaction With Symbiont
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
MAPK Cascade
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Axon Guidance
Aging
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Positive Regulation Of Actin Filament Polymerization
T Cell Costimulation
Actin Cytoskeleton Reorganization
Receptor Internalization
Entry Of Bacterium Into Host Cell
Interleukin-15-mediated Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of MAPK Cascade
Positive Regulation Of Ras Protein Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Anatomical Structure Formation Involved In Morphogenesis
Leukocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Branching Involved In Labyrinthine Layer Morphogenesis
Membrane Organization
Cellular Response To Ionizing Radiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Extracellular matrix organization
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Interleukin-15 signaling
Interleukin-15 signaling
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Drugs
Zinc
Lanoteplase
Ocriplasmin
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Pegademase
4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Blood protein levels (
28240269
)
Cholesterol, total (
26780889
)
Coronary artery disease (
32469254
29212778
28714974
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
32203549
28334899
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Negative urgency (
30718321
)
Pulse pressure (
28135244
27841878
30578418
)
Systolic blood pressure (
27841878
30578418
)
Total cholesterol levels (
28334899
)
White blood cell count (
32888494
)
Deep white matter hyperintensities (
32517579
)
Multiple sclerosis (
31604244
)
Systemic lupus erythematosus (
29848360
26502338
28714469
)
Systemic sclerosis (
31672989
)
Triglyceride levels (
32203549
)
Interacting Genes
105 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COMP
CRP
CTSD
CXCL12
DCN
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HRG
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
SCGB1A1
SDC2
SGCA
SH3GLB1
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TMPRSS6
TNC
TNFRSF11B
TSHR
TTN
UBQLN1
VEGFA
VHL
399 interacting genes:
A2M
ABI3
ABI3BP
ABL1
ABL2
ACAP1
ADA
ADAM12
ADAM15
ADRB1
ADRB2
AEBP1
AGR2
AGT
AHSG
AJUBA
ALAS2
ALOX5
AMBP
ANKRD13A
ANKRD23
ANXA2
AP4S1
APCS
APOH
APP
AR
ARHGAP17
ARHGAP32
ARHGAP35
ARID5A
ASAP1
ASAP2
AUNIP
AXL
B2M
BCAR1
BCL2A1
BCR
BLNK
BPGM
BTG1
C1orf94
C21orf58
C21orf91
CALD1
CASC3
CASP2
CBL
CBLB
CBLC
CCDC28B
CCL5
CD164
CD19
CD22
CD247
CD28
CD2AP
CD72
CDC42
CDKN1B
CFH
CHRM4
CHRND
CKS2
CLNK
CLU
COPB1
COX6A1
CPSF7
CRBN
CRK
CRKL
CSF1R
CSF3R
CSN2
CTTN
CUTA
DAB2
DAG1
DCTN1
DCTN2
DDIT4L
DDX17
DLGAP1
DNAJA3
DNAJB11
DNM1
DNM2
DOCK4
DPPA4
DRD3
DRD4
DTX1
DTX3
DVL2
E2F2
ECHS1
EFHC2
EGF
EGFR
ELK1
ENO1
EP300
EPHA2
EPHB1
EPHB2
EPHB6
EPOR
EPS15
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESD
ESR1
ETV6
FABP1
FASLG
FCGR2A
FCGR2B
FGFR1
FGFR3
FH
FHOD1
FLT1
FLT3
FLT4
FN1
FRS2
FRS3
FTH1
FTL
FYN
GAB1
GAB2
GAB3
GAREM1
GC
GGN
GHR
GIT1
GPANK1
GRAP2
GRB7
GSTK1
H1-0
HCLS1
HELZ
HIPK3
HNRNPC
HNRNPK
HOMEZ
HP
HRAS
HSPA5
HTT
IK
IKZF3
IL2RB
INCA1
INPP5D
IRS1
IRS2
IRS4
ITGA2B
ITGA6
ITGB4
ITIH4
ITK
JAK1
JAK2
KDR
KHDRBS1
KHDRBS2
KIAA0408
KIAA1549L
KIF3A
KIT
KPNA2
KPRP
KRT8
LAT
LAT2
LAX1
LCP2
LIME1
LMO2
LNX1
LNX2
LY6G6F
LZTS2
MAP1A
MAP2
MAP4K1
MAP4K3
MAP4K5
MAPK1
MAPK12
MAPK14
MAPK9
MAPT
MED19
MED28
MEI4
MERTK
MET
METTL27
MIA2
MICAL1
MLXIPL
MS4A2
MSI2
MST1R
MT-ATP8
MT-ND4
MTA1
MTA3
MUC1
MYG1
MYH11
MYH9
MYO18A
MYOZ1
NADK
NAP1L5
NCKIPSD
NCL
NEU3
NFYB
NGFR
NIF3L1
NKD2
NPM1
NTRK1
NUTM2F
OCRL
OLIG1
PACRGL
PAG1
PAK1
PAK2
PAK4
PBXIP1
PCDHB5
PDCD6IP
PDE4D
PDE6G
PDGFRB
PHACTR4
PHC2
PHETA1
PIK3AP1
PIK3C2B
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLEKHA7
PNMA5
PNRC1
POLR1D
POLR2A
POMP
PON2
PPP3CA
PRAP1
PRKAB1
PRKAR1A
PRNP
PRR22
PRR5-ARHGAP8
PRRC2A
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN22
PTPN6
PTPRA
PTPRC
PTPRE
PXN
RALGPS1
RAPGEF1
RAPSN
RASA1
RBBP6
RBM33
RBP4
REL
REPS1
REPS2
RET
RHOU
RIF1
RNF10
RNF208
RPS6KA1
SELL
SF3A2
SF3B4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D4A
SH3BP2
SH3D19
SH3KBP1
SHANK3
SHB
SHBG
SHC1
SHC2
SHC3
SHC4
SHKBP1
SIGLEC7
SIT1
SKAP1
SLC1A2
SLX1A
SNRNP200
SNTA1
SOCS1
SOCS7
SOS1
SOS2
SPATA2L
SPRY1
SPRY2
SPTBN1
SRC
SS18
STAMBP
STK32C
STRADB
SYK
SYN1
SYNCRIP
SYNJ1
SYNJ2
SYP
TBC1D3B
TBC1D3G
TCEAL8
TCERG1
TEK
TF
TFG
TLE5
TNFRSF1A
TNK2
TOM1L1
TP53BP2
TP63
TRAT1
TRIB3
TRIM27
TSC2
TSPAN2
TUB
TXK
TYRO3
UBA1
UBA52
UBC
UQCC2
USP53
USP6NL
USP8
VAV1
VAV2
VAV3
VIM
VPS37C
WAS
WASF1
WASF2
WASL
WBP11
WDFY3
WDR1
WDR44
WIPF1
WIPF2
YLPM1
ZAP70
ZBTB12
ZBTB7B
ZMAT1
ZNF341
ZNF474
ZNF620
Entrez ID
2335
2885
HPRD ID
00626
00150
Ensembl ID
ENSG00000115414
ENSG00000177885
Uniprot IDs
B7ZLE5
P02751
Q6MZF4
Q6MZM7
Q6N084
Q9UQS6
B0LPF3
P62993
PDB IDs
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
6NAJ
1AZE
1BM2
1BMB
1CJ1
1FHS
1FYR
1GCQ
1GFC
1GFD
1GHU
1GRI
1IO6
1JYQ
1JYR
1JYU
1QG1
1TZE
1X0N
1ZFP
2AOA
2AOB
2H46
2H5K
2HUW
2VVK
2VWF
2W0Z
3C7I
3IMD
3IMJ
3IN7
3IN8
3KFJ
3MXC
3MXY
3N7Y
3N84
3N8M
3OV1
3OVE
3S8L
3S8N
3S8O
3WA4
4P9V
4P9Z
5CDW
6ICG
6ICH
6SDF
6VK2
6WM1
6WO2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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