Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
RACGAP1 and AURKB
Data Source:
BioGRID
(enzymatic study, enzymatic study)
HPRD
(in vivo, in vitro)
RACGAP1
AURKB
Description
Rac GTPase activating protein 1
aurora kinase B
Image
GO Annotations
Cellular Component
Acrosomal Vesicle
Nucleus
Nucleoplasm
Spindle
Cytosol
Microtubule
Midbody
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cleavage Furrow
Spindle Midzone
Extracellular Exosome
Mitotic Spindle
Flemming Body
Centralspindlin Complex
Kinetochore
Condensed Chromosome, Centromeric Region
Nucleus
Nucleoplasm
Spindle
Cytosol
Spindle Microtubule
Chromocenter
Midbody
Spindle Pole Centrosome
Chromosome Passenger Complex
Spindle Midzone
Mitotic Spindle Pole
Mitotic Spindle Midzone
Molecular Function
GTPase Activator Activity
Protein Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Microtubule Binding
Protein Kinase Binding
Alpha-tubulin Binding
Gamma-tubulin Binding
Metal Ion Binding
Beta-tubulin Binding
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Binding
Histone Serine Kinase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Mitotic Cytokinesis
Actomyosin Contractile Ring Assembly
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Microtubule-based Movement
Spermatogenesis
Neuroblast Proliferation
Sulfate Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of Cytokinesis
Intracellular Signal Transduction
Positive Regulation Of GTPase Activity
Regulation Of Embryonic Development
Regulation Of Small GTPase Mediated Signal Transduction
Mitotic Spindle Midzone Assembly
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Spindle Organization
Mitotic Spindle Organization
Mitotic Spindle Assembly Checkpoint
Aging
Cell Population Proliferation
Attachment Of Spindle Microtubules To Kinetochore
Abscission
Histone Modification
Anaphase-promoting Complex-dependent Catabolic Process
Negative Regulation Of Protein Binding
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Cytokinesis
Negative Regulation Of Cytokinesis
Positive Regulation Of Cytokinesis
Protein Localization To Kinetochore
Cellular Response To UV
Cleavage Furrow Formation
Histone H3-S28 Phosphorylation
Mitotic Cytokinesis Checkpoint
Protein Autophosphorylation
Mitotic Spindle Midzone Assembly
Positive Regulation Of Telomerase Activity
Regulation Of Chromosome Segregation
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Telomere Capping
Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways
Rho GTPase cycle
MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Regulation of TP53 Activity through Phosphorylation
Mitotic Prometaphase
Regulation of MECP2 expression and activity
EML4 and NUDC in mitotic spindle formation
Drugs
Hesperidin
AT9283
Enzastaurin
Reversine
Fostamatinib
Diseases
GWAS
Anxiety disorders (
31906708
)
Apolipoprotein A1 levels (
32203549
)
Interacting Genes
32 interacting genes:
AURKB
BYSL
CDK1
CDK3
CHN2
ECT2
HIF1A
KIF23
MAP3K10
MAP3K4
MORF4L1
MPRIP
NRAS
PLK1
PPP2CA
PPP2R5E
PRC1
PRSS23
PTPA
RAC1
RND2
SH3RF1
SLC16A10
SLC26A8
TANK
TRAF3IP3
TUBA4A
TUBG1
TXNDC11
VAV1
YWHAB
YWHAG
52 interacting genes:
AJUBA
ANKZF1
APP
BCL2L11
BIRC5
CBX3
CDCA8
CENPA
CIB1
CYLD
DCUN1D1
DES
EVI5
FBXL2
FLOT1
GFAP
H3-4
H3C1
H3C14
HASPIN
INCENP
KLHL13
KLHL21
KLHL9
LATS1
LATS2
LNX1
LRRK2
MAPRE1
MAPRE2
MAPRE3
MFHAS1
NCAPH
NDC80
NINL
NSUN2
NUF2
PKM
PSMA3
PTPA
RACGAP1
RACK1
RAD52
RASA1
RASSF1
SEPTIN1
SKA1
SKA3
TACC1
TBL3
TGFBR1
UBE2I
Entrez ID
29127
9212
HPRD ID
05402
05397
Ensembl ID
ENSG00000161800
ENSG00000178999
Uniprot IDs
A0A024R136
B2RE34
Q9H0H5
Q96GD4
PDB IDs
2OVJ
3W6R
3WPQ
3WPS
4B6D
5C2J
5C2K
4AF3
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?