AURKB and DCUN1D1

Data Source:
BioGRID (pull down)

		AURKB	DCUN1D1
Description		aurora kinase B	defective in cullin neddylation 1 domain containing 1
Image
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Midzone	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Spindle Organization Mitotic Spindle Organization Mitotic Spindle Assembly Checkpoint Aging Cell Population Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Histone H3-S28 Phosphorylation Mitotic Cytokinesis Checkpoint Protein Autophosphorylation Mitotic Spindle Midzone Assembly Positive Regulation Of Telomerase Activity Regulation Of Chromosome Segregation Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomere Capping Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore	Regulation Of Protein Ubiquitination Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation	Neddylation
Drugs		Hesperidin AT9283 Enzastaurin Reversine Fostamatinib
Diseases
GWAS		Anxiety disorders ( 31906708) Apolipoprotein A1 levels ( 32203549)	Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		52 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KLHL13 KLHL21 KLHL9 LATS1 LATS2 LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I	33 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B
Entrez ID		9212	54165
HPRD ID		05397	12067
Ensembl ID		ENSG00000178999	ENSG00000043093
Uniprot IDs		Q96GD4	B4DM76 C9JVE2 Q96GG9
PDB IDs		4AF3	3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W
Enriched GO Terms of Interacting Partners?
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