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RACGAP1 and PPP2R5E
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
RACGAP1
PPP2R5E
Description
Rac GTPase activating protein 1
protein phosphatase 2 regulatory subunit B'epsilon
Image
No pdb structure
GO Annotations
Cellular Component
Acrosomal Vesicle
Nucleus
Nucleoplasm
Spindle
Cytosol
Microtubule
Midbody
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cleavage Furrow
Spindle Midzone
Extracellular Exosome
Mitotic Spindle
Flemming Body
Centralspindlin Complex
Protein Phosphatase Type 2A Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
GTPase Activator Activity
Protein Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Microtubule Binding
Protein Kinase Binding
Alpha-tubulin Binding
Gamma-tubulin Binding
Metal Ion Binding
Beta-tubulin Binding
Protein Binding
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
Biological Process
Mitotic Cytokinesis
Actomyosin Contractile Ring Assembly
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Microtubule-based Movement
Spermatogenesis
Neuroblast Proliferation
Sulfate Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of Cytokinesis
Intracellular Signal Transduction
Positive Regulation Of GTPase Activity
Regulation Of Embryonic Development
Regulation Of Small GTPase Mediated Signal Transduction
Mitotic Spindle Midzone Assembly
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Protein Dephosphorylation
Signal Transduction
Regulation Of Protein Autophosphorylation
Regulation Of Phosphoprotein Phosphatase Activity
Pathways
Rho GTPase cycle
MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Low density lipoprotein cholesterol levels (
32154731
)
Response to antineoplastic agents (
21659360
)
Systolic blood pressure (
28135244
)
Triglyceride levels (
32154731
)
Interacting Genes
32 interacting genes:
AURKB
BYSL
CDK1
CDK3
CHN2
ECT2
HIF1A
KIF23
MAP3K10
MAP3K4
MORF4L1
MPRIP
NRAS
PLK1
PPP2CA
PPP2R5E
PRC1
PRSS23
PTPA
RAC1
RND2
SH3RF1
SLC16A10
SLC26A8
TANK
TRAF3IP3
TUBA4A
TUBG1
TXNDC11
VAV1
YWHAB
YWHAG
20 interacting genes:
APP
BHLHB9
BHLHE41
CHEK2
CLOCK
CRY1
CRY2
CSNK1E
CSNK2B
DELEC1
DOCK9
ENO1
FBXW11
PPP1CA
PPP2CA
PPP2R1B
RACGAP1
RORC
SGO1
SMAD9
Entrez ID
29127
5529
HPRD ID
05402
09040
Ensembl ID
ENSG00000161800
ENSG00000154001
Uniprot IDs
A0A024R136
B2RE34
Q9H0H5
Q16537
PDB IDs
2OVJ
3W6R
3WPQ
3WPS
4B6D
5C2J
5C2K
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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