SYNGAP1 and OSTF1

Data Source:
BioGRID (two hybrid)

		SYNGAP1	OSTF1
Description		synaptic Ras GTPase activating protein 1	osteoclast stimulating factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse	Extracellular Region Intracellular Anatomical Structure Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding	Protein Binding SH3 Domain Binding
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure	Ossification Signal Transduction Neutrophil Degranulation
Pathways		Regulation of RAS by GAPs	Neutrophil degranulation
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)	Allergic rhinitis ( 25085501) Glucose homeostasis traits ( 25524916) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Resting-state electroencephalogram vigilance ( 29703947) Systemic sclerosis ( 30247649) Urinary magnesium-to-creatinine ratio ( 29093028)
Interacting Genes		28 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX	51 interacting genes: AGR2 APP BORCS6 CBL CBLB CCDC33 CRX CTDSP1 CUEDC1 DPPA4 DTX3 EFS ERRFI1 FASLG FBXO7 GAPDH GGN HES7 HTT KHDRBS1 KLHL42 LATS1 LMNA MAPK6 MED19 MEOX2 NFYC NUTM1 NUTM2F PBX4 PICK1 REL RP2 SDCBP SF1 SF3A2 SMN1 SNW1 SOCS7 SYNGAP1 TRIB3 TRIM54 VPS37B WASF1 WASHC1 WASL YPEL3 ZBTB42 ZBTB7B ZNF655 ZNF688
Entrez ID		8831	26578
HPRD ID		16018	17808
Ensembl ID		ENSG00000197283	ENSG00000134996
Uniprot IDs		A0A1U9X8L0 B7ZCA0 Q96PV0	Q92882
PDB IDs			1X2K 1ZLM 3EHQ 3EHR
Enriched GO Terms of Interacting Partners?
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