CDH2 and CDON

Data Source:
HPRD (in vivo)

		CDH2	CDON
Description		cadherin 2	cell adhesion associated, oncogene regulated
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Collagen-containing Extracellular Matrix Integral Component Of Presynaptic Active Zone Membrane Integral Component Of Postsynaptic Specialization Membrane	Plasma Membrane Integral Component Of Plasma Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding	Protein Binding
	Biological Process	Type B Pancreatic Cell Development Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Assembly Brain Development Glial Cell Differentiation Neural Crest Cell Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebral Cortex Development Adherens Junction Organization Detection Of Muscle Stretch Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Regulation Of Axonogenesis Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Regulation Of Synaptic Transmission, Glutamatergic Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Migration Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering	Cell Fate Specification Positive Regulation Of Protein Phosphorylation Lens Development In Camera-type Eye Cell Adhesion Smoothened Signaling Pathway Myoblast Fusion Anterior/posterior Pattern Specification Embryonic Body Morphogenesis Skeletal Muscle Satellite Cell Differentiation Cerebral Cortex Development Regulation Of Protein Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Muscle Cell Differentiation Embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation	Myogenesis Myogenesis Ligand-receptor interactions Activation of SMO
Drugs
Diseases
GWAS		Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Periodontal disease-related phenotype (Socransky) ( 24347629) PR interval ( 32439900) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Resting heart rate ( 27798624) Temperament (bipolar disorder) ( 22365631) Type 2 diabetes ( 31049640) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) vWF and FVIII levels ( 21810271)	Alzheimer's disease (late onset) ( 22881374) Blood protein levels ( 30072576 29875488 28240269) Cerebral white matter volume ( 31530798) Height ( 31562340) Lung function (FEV1) ( 28166213) Mild to moderate chronic kidney disease ( 31178898) Primary tooth development (time to first tooth eruption) ( 23704328) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC	5 interacting genes: ABL1 BOC CDH15 CDH2 CTNNB1
Entrez ID		1000	50937
HPRD ID		00226	16372
Ensembl ID		ENSG00000170558	ENSG00000064309
Uniprot IDs		A0A024RC42 C9J126 P19022	Q4KMG0
PDB IDs			3D1M 3N1F 3N1Q
Enriched GO Terms of Interacting Partners?
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