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NEK2 and PPP1CA
Data Source:
BioGRID
(two hybrid)
HPRD
(in vitro, in vivo, two hybrid)
NEK2
PPP1CA
Description
NIMA related kinase 2
protein phosphatase 1 catalytic subunit alpha
Image
GO Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Microtubule
Midbody
Protein-containing Complex
Protein Phosphatase Type 1 Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Glycogen Granule
Dendritic Spine
Perikaryon
Extracellular Exosome
PTW/PP1 Phosphatase Complex
Presynapse
Glutamatergic Synapse
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase 1 Binding
Phosphatase Activity
Ribonucleoprotein Complex Binding
Metal Ion Binding
Cadherin Binding Involved In Cell-cell Adhesion
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Blastocyst Development
Protein Phosphorylation
Chromosome Segregation
Regulation Of Mitotic Nuclear Division
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of DNA Binding
Regulation Of Mitotic Centrosome Separation
Protein Autophosphorylation
Spindle Assembly
Centrosome Separation
Cell Division
Meiotic Cell Cycle
Positive Regulation Of Telomerase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Mitotic Spindle Assembly
Ciliary Basal Body-plasma Membrane Docking
Negative Regulation Of Centriole-centriole Cohesion
Positive Regulation Of Telomere Capping
Glycogen Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Glycogen Catabolic Process
Protein Dephosphorylation
Cell Cycle
Response To Lead Ion
Viral Process
Dephosphorylation
Lung Development
Negative Regulation Of Protein Binding
Circadian Regulation Of Gene Expression
Peptidyl-threonine Dephosphorylation
Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Branching Morphogenesis Of An Epithelial Tube
Cell Division
Regulation Of Canonical Wnt Signaling Pathway
Peptidyl-serine Dephosphorylation
Cell-cell Adhesion
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
APC-Cdc20 mediated degradation of Nek2A
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Triglyceride catabolism
DARPP-32 events
Downregulation of TGF-beta receptor signaling
Circadian Clock
Drugs
5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide
Fostamatinib
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases
GWAS
Red cell distribution width (
32888494
27863252
28957414
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Height (
28552196
)
Interacting Genes
28 interacting genes:
CCDC85A
CDC20
CEP250
CHGA
CSN2
CTNNB1
DCTN1
EDRF1
EIF4A2
FZR1
GIT1
IFT140
IMMT
MAD1L1
MAPK1
MCC
NDC80
NEK11
PDE4DIP
PPP1CA
PPP1CC
PPP1R2
PRKN
PTPRD
SMURF1
SPTBN4
TCF25
TPM3
161 interacting genes:
AATK
AKAP1
AKAP11
AKAP9
APAF1
AURKA
BAD
BAX
BCL2
BCL2L1
BCL2L2
BRCA1
BTBD10
C1QA
CAD
CAV1
CCDC181
CDC5L
CDH1
CEP126
CEP170
CKB
CLCN2
CLOCK
CLTC
CNP
CNST
CNTN1
CREB1
CRK
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CUL1
CXXC1
DCTN1
DCX
DEAF1
DELEC1
DYNLT4
EED
EIF2AK2
ESR1
FRMPD4
FXYD1
GLIPR1L2
GPKOW
H2AX
H3-3A
H3C1
HEYL
HSPA4
IBTK
ID2
JPH3
KANK1
KCNQ1
KCTD20
KIF13A
KIF18A
KNL1
LMTK2
LPIN2
MAFG
MAL2
MAP4K4
MAPK1
MAPK3
MAPT
MIIP
MPHOSPH10
MST1R
MYO16
NCAM1
NDP
NEK2
NOC2L
NOM1
NONO
NOP53
PAK1
PCDH7
PCNA
PHACTR1
PHACTR3
PHACTR4
PHC1
PIAS1
PIAS3
PLCL2
POLR2A
PPP1R10
PPP1R11
PPP1R13B
PPP1R13L
PPP1R15A
PPP1R15B
PPP1R16A
PPP1R16B
PPP1R18
PPP1R1B
PPP1R2
PPP1R26
PPP1R27
PPP1R2B
PPP1R2C
PPP1R32
PPP1R37
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R3E
PPP1R3G
PPP1R7
PPP1R8
PPP1R9A
PPP1R9B
PPP2CA
PPP2R5C
PPP2R5E
PREX1
PRKCB
PRKCD
PRR16
PTEN
PTPN7
PYGM
RANBP9
RB1
RIF1
RORC
RPRD2
SFPQ
SFRP1
SH3RF2
SKP1
SLC45A1
SORL1
SPRED1
STAM
STAU1
SYTL2
TOE1
TOR1AIP1
TOX4
TP53
TP53BP2
TPRN
TUSC3
UBE2Z
ULK1
VDR
WBP11
WDR82
WWTR1
YLPM1
ZBTB11
ZFYVE16
ZFYVE9
ZNF827
Entrez ID
4751
5499
HPRD ID
04953
15942
Ensembl ID
ENSG00000117650
ENSG00000172531
Uniprot IDs
F6U4U2
P51955
A0A140VJS9
P62136
PDB IDs
2JAV
2W5A
2W5B
2W5H
2WQO
2XK3
2XK4
2XK6
2XK7
2XK8
2XKC
2XKD
2XKE
2XKF
2XNM
2XNN
2XNO
2XNP
4A4X
4AFE
5M51
5M53
5M55
5M57
6SGD
6SGH
6SGI
6SGK
6SK9
6TM5
3E7A
3E7B
3EGG
3EGH
3HVQ
3N5U
3V4Y
4G9J
4MOV
4MOY
4MP0
4XPN
5IOH
6ALZ
6CZO
6DCX
6DNO
6G0I
6G0J
6GHM
6OBN
6OBP
6OBQ
6OBR
6OBS
6OBU
6ZEE
6ZEF
6ZEG
6ZEH
6ZEI
6ZEJ
Enriched GO Terms of Interacting Partners
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