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GLP1R and HAMP
Data Source:
BioGRID
(protein complementation assay)
GLP1R
HAMP
Description
glucagon like peptide 1 receptor
hepcidin antimicrobial peptide
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Extracellular Region
Extracellular Space
Nucleus
Intercalated Disc
Apical Cortex
Molecular Function
Transmembrane Signaling Receptor Activity
Glucagon Receptor Activity
Protein Binding
G Protein-coupled Peptide Receptor Activity
Peptide Hormone Binding
Glucagon-like Peptide 1 Receptor Activity
Hormone Activity
Copper Ion Binding
Biological Process
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
CAMP-mediated Signaling
Positive Regulation Of Blood Pressure
Regulation Of Insulin Secretion
Cellular Response To Glucagon Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
Myeloid Cell Homeostasis
Cellular Iron Ion Homeostasis
Acute-phase Response
Immune Response
Receptor Signaling Pathway Via JAK-STAT
Aging
Response To Iron Ion
Response To Zinc Ion
Killing Of Cells Of Other Organism
Response To Vitamin A
Negative Regulation Of Iron Ion Transmembrane Transport
Response To Erythropoietin
Defense Response To Bacterium
Positive Regulation Of Macrophage Activation
Response To Ethanol
Negative Regulation Of Bone Resorption
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Defense Response To Fungus
Multicellular Organismal Iron Ion Homeostasis
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To X-ray
Liver Regeneration
Positive Regulation Of Cellular Protein Catabolic Process
Cellular Response To Bile Acid
Negative Regulation Of Intestinal Absorption
Response To Iron Ion Starvation
Pathways
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Glucagon
Exenatide
Liraglutide
Albiglutide
Dulaglutide
Lixisenatide
Semaglutide
Diseases
Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS
Blood sugar levels (
29403010
)
Fasting blood glucose (
25631608
)
Fasting blood glucose adjusted for BMI (
25625282
)
Type 2 diabetes (
32499647
)
Irritable bowel syndrome (
29673008
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Red cell distribution width (
32888494
28957414
)
Interacting Genes
112 interacting genes:
ACSF3
AGXT
AIG1
APH1A
ARFRP1
ASGR2
ATP13A1
ATP5MC3
ATP6AP2
C18orf32
C4orf3
CALM1
CAND2
CAV1
CCDC167
CD63
CD81
CELA3B
CEND1
CFI
CLDN7
CLIP4
CLPS
CNIH4
COMT
CYSRT1
CYSTM1
DAD1
DHRS7
EBP
ELOVL1
EMC7
EMP2
ERP29
FGL1
FTL
GABBR2
GCG
GJB1
GNAS
GP2
GPR108
GPR37
GPRASP1
GRINA
HAMP
HPN
IER3
IFITM3
KHK
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP17-1
KRTAP5-9
LAPTM4A
LINC00269
MFSD5
MRPL22
MT-ATP6
MT-ND4L
MTCH2
MYL6
NBPF19
NOTCH2NLA
NRGN
NUCKS1
OCIAD2
OST4
P4HTM
PAM
PAQR6
PGRMC1
PIGG
POMT2
PPIB
PRSS2
PSMD8
RAB5B
RAB5C
RNF5
RTN3
RTN4
RTRAF
SAA1
SCGB2A1
SEC11C
SELENOK
SERPINA1
SLC15A4
SLC37A4
SPTSSA
STMN1
STMN3
STOML2
SVOP
SYNGR3
SYNGR4
SYS1
TM4SF4
TMBIM6
TMCO3
TMEM147
TMEM176B
TOMM6
TSPAN13
UGT1A9
VAPB
ZNF99
4 interacting genes:
CKAP4
GLP1R
SLC40A1
VKORC1
Entrez ID
2740
57817
HPRD ID
00677
05925
Ensembl ID
ENSG00000112164
ENSG00000105697
Uniprot IDs
A0A142FHB8
P43220
P81172
PDB IDs
3C59
3C5T
3IOL
4ZGM
5E94
5NX2
5OTT
5OTU
5OTV
5OTW
5OTX
5VEW
5VEX
6B3J
6GB1
6ORV
6VCB
6X18
6X19
6X1A
7C2E
1M4E
1M4F
2KEF
3H0T
4QAE
6WBV
Enriched GO Terms of Interacting Partners
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