HAMP and SLC40A1

Data Source:
HPRD (in vivo)

		HAMP	SLC40A1
Description		hepcidin antimicrobial peptide	solute carrier family 40 member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Intercalated Disc Apical Cortex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Hormone Activity Copper Ion Binding	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Myeloid Cell Homeostasis Cellular Iron Ion Homeostasis Acute-phase Response Immune Response Receptor Signaling Pathway Via JAK-STAT Aging Response To Iron Ion Response To Zinc Ion Killing Of Cells Of Other Organism Response To Vitamin A Negative Regulation Of Iron Ion Transmembrane Transport Response To Erythropoietin Defense Response To Bacterium Positive Regulation Of Macrophage Activation Response To Ethanol Negative Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Defense Response To Fungus Multicellular Organismal Iron Ion Homeostasis Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To X-ray Liver Regeneration Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Bile Acid Negative Regulation Of Intestinal Absorption Response To Iron Ion Starvation	Cellular Iron Ion Homeostasis Iron Ion Transmembrane Transport Iron Ion Homeostasis Multicellular Organismal Iron Ion Homeostasis Inorganic Cation Transmembrane Transport Iron Ion Export Across Plasma Membrane
Pathways			Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport
Drugs
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)	Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Irritable bowel syndrome ( 29673008) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 28957414)	Bone fracture in osteoporosis ( 28580392) Hematocrit ( 32888494) Iron status biomarkers (ferritin levels) ( 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 32888494)
Interacting Genes		4 interacting genes: CKAP4 GLP1R SLC40A1 VKORC1	3 interacting genes: GOLM1 HAMP SLC22A2
Entrez ID		57817	30061
HPRD ID		05925	05229
Ensembl ID		ENSG00000105697	ENSG00000138449
Uniprot IDs		P81172	Q9NP59
PDB IDs		1M4E 1M4F 2KEF 3H0T 4QAE 6WBV	6W4S 6WBV
Enriched GO Terms of Interacting Partners?
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