HAMP

Description		hepcidin antimicrobial peptide
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Intercalated Disc Apical Cortex
	Molecular Function	Hormone Activity Copper Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Myeloid Cell Homeostasis Cellular Iron Ion Homeostasis Acute-phase Response Immune Response Receptor Signaling Pathway Via JAK-STAT Aging Response To Iron Ion Response To Zinc Ion Killing Of Cells Of Other Organism Response To Vitamin A Negative Regulation Of Iron Ion Transmembrane Transport Response To Erythropoietin Defense Response To Bacterium Positive Regulation Of Macrophage Activation Response To Ethanol Negative Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Defense Response To Fungus Multicellular Organismal Iron Ion Homeostasis Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To X-ray Liver Regeneration Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Bile Acid Negative Regulation Of Intestinal Absorption Response To Iron Ion Starvation
Pathways
Drugs
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Irritable bowel syndrome ( 29673008) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 28957414)
Novel Interacting Genes		1 novel interacting genes: EXOSC5
Interacting Genes		4 interacting genes: CKAP4 GLP1R SLC40A1 VKORC1
Entrez ID		57817
HPRD ID		05925
Ensembl ID		ENSG00000105697
Uniprot IDs		P81172
PDB IDs		1M4E 1M4F 2KEF 3H0T 4QAE 6WBV
Enriched GO Terms of Interacting Partners?
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