GLP1R and APH1A

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		GLP1R	APH1A
Description		glucagon like peptide 1 receptor	aph-1 homolog A, gamma-secretase subunit
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Mitochondrion Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex Integral Component Of Presynaptic Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Glucagon-like Peptide 1 Receptor Activity	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration CAMP-mediated Signaling Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs		Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide	E-2012
Diseases
GWAS		Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Type 2 diabetes ( 32499647)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26955885 26835600) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 C4orf3 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MFSD5 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMCO3 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99	36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1
Entrez ID		2740	51107
HPRD ID		00677	06360
Ensembl ID		ENSG00000112164	ENSG00000117362
Uniprot IDs		A0A142FHB8 P43220	B4DUG7 Q96BI3
PDB IDs		3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 7C2E	5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
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