HAMP and VKORC1

Data Source:
BioGRID (two hybrid)

		HAMP	VKORC1
Description		hepcidin antimicrobial peptide	vitamin K epoxide reductase complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Intercalated Disc Apical Cortex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Hormone Activity Copper Ion Binding	Protein Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Myeloid Cell Homeostasis Cellular Iron Ion Homeostasis Acute-phase Response Immune Response Receptor Signaling Pathway Via JAK-STAT Aging Response To Iron Ion Response To Zinc Ion Killing Of Cells Of Other Organism Response To Vitamin A Negative Regulation Of Iron Ion Transmembrane Transport Response To Erythropoietin Defense Response To Bacterium Positive Regulation Of Macrophage Activation Response To Ethanol Negative Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Defense Response To Fungus Multicellular Organismal Iron Ion Homeostasis Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To X-ray Liver Regeneration Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Bile Acid Negative Regulation Of Intestinal Absorption Response To Iron Ion Starvation	Blood Coagulation Response To Organonitrogen Compound Response To Organic Cyclic Compound Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Vitamin K Metabolic Process Response To Antibiotic Bone Development
Pathways			Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)	Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Irritable bowel syndrome ( 29673008) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 28957414)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		4 interacting genes: CKAP4 GLP1R SLC40A1 VKORC1	93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL METTL7B MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		57817	79001
HPRD ID		05925	10540
Ensembl ID		ENSG00000105697	ENSG00000167397
Uniprot IDs		P81172	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		1M4E 1M4F 2KEF 3H0T 4QAE 6WBV
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?