GLP1R and SEC11C

Data Source:
BioGRID (protein complementation assay)

		GLP1R	SEC11C
Description		glucagon like peptide 1 receptor	SEC11 homolog C, signal peptidase complex subunit
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Glucagon-like Peptide 1 Receptor Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration CAMP-mediated Signaling Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus	Signal Peptide Processing
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs		Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide
Diseases
GWAS		Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Type 2 diabetes ( 32499647)	Alzheimer's disease (age of onset) ( 22005931) Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 C4orf3 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MFSD5 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMCO3 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99	23 interacting genes: BTN2A2 C2 CADM3 GLP1R HMOX1 MFF PLPP6 PRSS23 RTP2 SCD SELENOM SERP1 STX12 TMEM128 TMEM243 TMEM254 TMEM42 TREX1 TSNARE1 UBE2J1 VAMP1 VAMP4 VAPA
Entrez ID		2740	90701
HPRD ID		00677	15310
Ensembl ID		ENSG00000112164	ENSG00000166562
Uniprot IDs		A0A142FHB8 P43220	K7EJQ7 Q9BY50
PDB IDs		3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 7C2E
Enriched GO Terms of Interacting Partners?
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