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GLP1R and RTN4
Data Source:
BioGRID
(protein complementation assay)
GLP1R
RTN4
Description
glucagon like peptide 1 receptor
reticulon 4
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Nuclear Envelope
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Postsynaptic Density
Integral Component Of Endoplasmic Reticulum Membrane
Cell Projection
Neuronal Cell Body
Endoplasmic Reticulum Tubular Network
Endoplasmic Reticulum Tubular Network Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Glucagon Receptor Activity
Protein Binding
G Protein-coupled Peptide Receptor Activity
Peptide Hormone Binding
Glucagon-like Peptide 1 Receptor Activity
RNA Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Cadherin Binding
Biological Process
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
CAMP-mediated Signaling
Positive Regulation Of Blood Pressure
Regulation Of Insulin Secretion
Cellular Response To Glucagon Stimulus
Blastocyst Formation
Apoptotic Process
Axonal Fasciculation
Positive Regulation Of Epithelial Cell Migration
Cerebral Cortex Radial Glia Guided Migration
Negative Regulation Of Cell Growth
Negative Regulation Of Axon Extension
Positive Regulation Of Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Axonogenesis
Protein Stabilization
Nuclear Pore Complex Assembly
Positive Regulation Of Protein Kinase B Signaling
Cardiac Epithelial To Mesenchymal Transition
Protein Localization To Lysosome
Endoplasmic Reticulum Tubular Network Organization
Endoplasmic Reticulum Tubular Network Formation
Cellular Sphingolipid Homeostasis
Negative Regulation Of Amyloid-beta Formation
Positive Regulation Of Protein Localization To Endoplasmic Reticulum
Positive Regulation Of ERBB3 Signaling Pathway
Endoplasmic Reticulum Tubular Network Membrane Organization
Regulation Of Branching Morphogenesis Of A Nerve
Pathways
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Axonal growth inhibition (RHOA activation)
Drugs
Glucagon
Exenatide
Liraglutide
Albiglutide
Dulaglutide
Lixisenatide
Semaglutide
Diseases
GWAS
Blood sugar levels (
29403010
)
Fasting blood glucose (
25631608
)
Fasting blood glucose adjusted for BMI (
25625282
)
Type 2 diabetes (
32499647
)
Adult body size (
32376654
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Obesity (extreme) (
19553259
)
Platelet count (
32888494
)
Systolic blood pressure (
30224653
)
Interacting Genes
112 interacting genes:
ACSF3
AGXT
AIG1
APH1A
ARFRP1
ASGR2
ATP13A1
ATP5MC3
ATP6AP2
C18orf32
C4orf3
CALM1
CAND2
CAV1
CCDC167
CD63
CD81
CELA3B
CEND1
CFI
CLDN7
CLIP4
CLPS
CNIH4
COMT
CYSRT1
CYSTM1
DAD1
DHRS7
EBP
ELOVL1
EMC7
EMP2
ERP29
FGL1
FTL
GABBR2
GCG
GJB1
GNAS
GP2
GPR108
GPR37
GPRASP1
GRINA
HAMP
HPN
IER3
IFITM3
KHK
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP17-1
KRTAP5-9
LAPTM4A
LINC00269
MFSD5
MRPL22
MT-ATP6
MT-ND4L
MTCH2
MYL6
NBPF19
NOTCH2NLA
NRGN
NUCKS1
OCIAD2
OST4
P4HTM
PAM
PAQR6
PGRMC1
PIGG
POMT2
PPIB
PRSS2
PSMD8
RAB5B
RAB5C
RNF5
RTN3
RTN4
RTRAF
SAA1
SCGB2A1
SEC11C
SELENOK
SERPINA1
SLC15A4
SLC37A4
SPTSSA
STMN1
STMN3
STOML2
SVOP
SYNGR3
SYNGR4
SYS1
TM4SF4
TMBIM6
TMCO3
TMEM147
TMEM176B
TOMM6
TSPAN13
UGT1A9
VAPB
ZNF99
47 interacting genes:
BAIAP2
BCL2
BCL2L1
BDKRB1
CCR4
CERT1
CHRM4
CLN8
CNTNAP1
CRMP1
CYSLTR2
DRD2
ERBB2
ERBB3
ERBB4
F2RL1
FXR2
GLP1R
GPR35
HLA-DPB1
HTR2C
LAMA4
LINC01554
LMNA
LRCH4
LRPAP1
MBP
NAPA
NR4A1
PLEKHF2
POT1
PRR13
RAB33A
RPS27
RTN3
RTN4IP1
RTN4R
SNX1
SNX15
SPG21
SYT16
TERF1
TUBA4A
UQCRC1
UQCRC2
WWP1
ZFYVE21
Entrez ID
2740
57142
HPRD ID
00677
07259
Ensembl ID
ENSG00000112164
ENSG00000115310
Uniprot IDs
A0A142FHB8
P43220
Q9NQC3
PDB IDs
3C59
3C5T
3IOL
4ZGM
5E94
5NX2
5OTT
5OTU
5OTV
5OTW
5OTX
5VEW
5VEX
6B3J
6GB1
6ORV
6VCB
6X18
6X19
6X1A
7C2E
2G31
2JV5
Enriched GO Terms of Interacting Partners
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