LSM1 and LSM7

Data Source:
HPRD (in vitro)

		LSM1	LSM7
Description		LSM1 homolog, mRNA degradation associated	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Axon Dendrite Neuronal Cell Body Messenger Ribonucleoprotein Complex Lsm1-7-Pat1 Complex	Nucleus Nucleoplasm U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Cap Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding	RNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Metabolic Process Stem Cell Population Maintenance Exonucleolytic Catabolism Of Deadenylated MRNA Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process	MRNA Splicing, Via Spliceosome Exonucleolytic Catabolism Of Deadenylated MRNA
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 22037555 29483656)	Parkinson's disease ( 28892059)
Interacting Genes		32 interacting genes: AGR2 AGR3 BEX5 CLIC1 DAPL1 EXOSC6 EXOSC8 GLUD1 GRHPR GSTA4 HSP90AA1 LSM2 LSM3 LSM5 LSM6 LSM7 MCCD1 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TCL1B TFCP2 TMEM214 UPF2 UXT VPS11	25 interacting genes: DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SART3 SMN1 SNRPD3 SNRPF SYT17 TACC1 TCL1B ZSCAN26
Entrez ID		27257	51690
HPRD ID		06281	06287
Ensembl ID		ENSG00000175324	ENSG00000130332
Uniprot IDs		A0A0S2Z590 O15116	Q9UK45
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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