LSM1 and LSM3

Data Source:
HPRD (in vitro)

		LSM1	LSM3
Description		LSM1 homolog, mRNA degradation associated	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Axon Dendrite Neuronal Cell Body Messenger Ribonucleoprotein Complex Lsm1-7-Pat1 Complex	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex
	Molecular Function	RNA Cap Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Metabolic Process Stem Cell Population Maintenance Exonucleolytic Catabolism Of Deadenylated MRNA Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process	MRNA Splicing, Via Spliceosome MRNA Processing P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 22037555 29483656)	Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		32 interacting genes: AGR2 AGR3 BEX5 CLIC1 DAPL1 EXOSC6 EXOSC8 GLUD1 GRHPR GSTA4 HSP90AA1 LSM2 LSM3 LSM5 LSM6 LSM7 MCCD1 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TCL1B TFCP2 TMEM214 UPF2 UXT VPS11	48 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN TFIP11 THOC5 TRAPPC2 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		27257	27258
HPRD ID		06281	06283
Ensembl ID		ENSG00000175324	ENSG00000170860
Uniprot IDs		A0A0S2Z590 O15116	P62310
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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