LSM7 and RASSF5

Data Source:
BioGRID (two hybrid)

		LSM7	RASSF5
Description		LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated	Ras association domain family member 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Nucleus Cytoplasm Microtubule
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	Protein Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Exonucleolytic Catabolism Of Deadenylated MRNA	Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Nucleus
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Parkinson's disease ( 28892059)	Inflammatory bowel disease ( 23128233) Late-onset Alzheimer's disease ( 27770636) Neurofibrillary tangles ( 25188341)
Interacting Genes		25 interacting genes: DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SART3 SMN1 SNRPD3 SNRPF SYT17 TACC1 TCL1B ZSCAN26	31 interacting genes: ADH6 AMOTL2 APPBP2 BTRC HRAS ITCH KRAS KRT40 KRTAP4-2 LSM7 MRAS MYLIP NRAS RABIF RALA RAP1B RAP2A RAP2B RASSF1 RASSF2 REL RRAS RRAS2 SMAD4 STK4 TERF2IP TRAF1 TRAF2 UBQLN1 UBQLN2 VPS28
Entrez ID		51690	83593
HPRD ID		06287	06117
Ensembl ID		ENSG00000130332	ENSG00000266094
Uniprot IDs		Q9UK45	A8K5F3 Q8WWW0
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	4LGD 4OH8
Enriched GO Terms of Interacting Partners?
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