Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
BCL2L1 and PSEN1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid, in vivo)
BCL2L1
PSEN1
Description
BCL2 like 1
presenilin 1
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Centrosome
Cytosol
Integral Component Of Membrane
Synaptic Vesicle Membrane
Nuclear Membrane
Bcl-2 Family Protein Complex
Golgi Membrane
Kinetochore
Nucleus
Nuclear Outer Membrane
Nucleoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Synaptic Vesicle
Cell Surface
Membrane
Integral Component Of Membrane
Aggresome
Apical Plasma Membrane
Z Disc
Cell Junction
Growth Cone
Neuromuscular Junction
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Ciliary Rootlet
Azurophil Granule Membrane
Sarcolemma
Neuron Projection
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Gamma-secretase Complex
Integral Component Of Presynaptic Membrane
Molecular Function
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
BH3 Domain Binding
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
PDZ Domain Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Cadherin Binding
ATPase Binding
Growth Factor Receptor Binding
Biological Process
Release Of Cytochrome C From Mitochondria
Endocytosis
Mitotic Cell Cycle Checkpoint
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Apoptotic Mitochondrial Changes
Suppression By Virus Of Host Apoptotic Process
Cytokine-mediated Signaling Pathway
Regulation Of Cytokinesis
Response To Cytokine
Negative Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Defense Response To Virus
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPKK Activity
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Hematopoietic Progenitor Cell Differentiation
Astrocyte Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
Neural Retina Development
Protein Glycosylation
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Mitochondrial Transport
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Notch Receptor Processing
Learning Or Memory
Memory
Post-embryonic Development
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Neuron Projection Development
Protein Transport
Choline Transport
Synaptic Vesicle Targeting
Protein Processing
Cerebellum Development
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Embryonic Limb Morphogenesis
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Phosphorylation
Positive Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Ephrin Receptor Signaling Pathway
Astrocyte Activation
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Synapse Organization
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Sequestering Of Calcium Ion
Neuron Apoptotic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Resting Membrane Potential
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Dendritic Spine Development
Calcium Ion Transmembrane Transport
Modulation Of Age-related Behavioral Decline
Cell-cell Adhesion
L-glutamate Import Across Plasma Membrane
Cellular Response To Amyloid-beta
Negative Regulation Of Core Promoter Binding
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Positive Regulation Of Amyloid Fibril Formation
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-4 and Interleukin-13 signaling
The NLRP1 inflammasome
RAS processing
STAT5 activation downstream of FLT3 ITD mutants
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Drugs
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
Isosorbide
Gossypol
Diseases
Acne inversa; Hidradenitis supprativa
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Alzheimer's disease (AD)
GWAS
Brain morphology (MOSTest) (
32665545
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Monocyte percentage of white cells (
27863252
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder (
26184070
)
Platelet count (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Prudent dietary pattern (
28644415
)
Putamen volume (
29147026
)
Subcortical brain region volumes (
25607358
)
Apolipoprotein B levels (
32203549
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
110 interacting genes:
ACTB
AKT1
ANTXR1
APAF1
AURKA
AVEN
BAD
BAG1
BAK1
BAX
BBC3
BCAP31
BCL2
BCL2L10
BCL2L11
BCL2L12
BCL2L14
BCLAF1
BECN1
BID
BIK
BLK
BMF
BNIP1
BNIP3
BNIP3L
BNIP5
BNIPL
C10orf67
CAPN1
CASP1
CASP8
CASP9
CDKN2A
CFLAR
CHEK1
CREB3
CRYAA
CRYAB
CYCS
DOCK7
EDRF1
ELOVL4
ERGIC3
FBP1
FKBP8
G0S2
GLOD4
GNLY
GOLM1
GORAB
GSK3A
GSK3B
HNRNPA1
HRK
IKZF3
IRS1
IRS2
LARP1
MAPK14
MAPK8
MAPK9
MAPKAPK2
MCL1
METTL23
MOAP1
MTIF3
MTNR1B
MTOR
NLRP1
PARK7
PDIA4
PLD3
PLK1
PLK3
PMAIP1
PPHLN1
PPP1CA
PRKN
PSEN1
PSEN2
PTN
RAD9A
RAF1
RBM5
REEP4
RHBDD2
RIC3
RNF183
RNF4
RTN1
RTN4
RYR3
SIVA1
SNCA
SPNS1
TLE1
TMBIM6
TMEM50B
TP53
TP53BP2
TPT1
UBE2I
UBR1
UHRF2
VAC14
VDAC1
ZFYVE1
ZHX1
ZNF219
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
Entrez ID
598
5663
HPRD ID
02497
00087
Ensembl ID
ENSG00000171552
ENSG00000080815
Uniprot IDs
A0A0S2Z3C5
Q07817
Q5TE63
A0A024R6A3
A0A0S2Z4D2
P49768
PDB IDs
1BXL
1G5J
1LXL
1MAZ
1R2D
1R2E
1R2G
1R2H
1R2I
1YSG
1YSI
1YSN
2B48
2LP8
2LPC
2M03
2M04
2ME8
2ME9
2MEJ
2O1Y
2O2M
2O2N
2P1L
2PON
2YJ1
2YQ6
2YQ7
2YXJ
3CVA
3FDL
3FDM
3INQ
3IO8
3PL7
3QKD
3R85
3SP7
3SPF
3WIZ
3ZK6
3ZLN
3ZLO
3ZLR
4A1U
4A1W
4AQ3
4BPK
4C52
4C5D
4CIN
4EHR
4HNJ
4IEH
4PPI
4QVE
4QVF
4QVX
4TUH
4Z9V
5AGW
5AGX
5B1Z
5C3G
5FMJ
5FMK
5VAY
5VX3
6BF2
6DCN
6DCO
6F46
6HJL
6IJQ
6O0K
6O0L
6O0M
6O0O
6O0P
6RNU
6ST2
6VWC
6X7I
6ZHC
7CA4
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?