ZNF438 and YES1

Data Source:
BioGRID (two hybrid)

		ZNF438	YES1
Description		zinc finger protein 438	YES proto-oncogene 1, Src family tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Golgi Apparatus Microtubule Organizing Center Cytosol Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Innate Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration
Pathways			Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Drugs			Dasatinib Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Congenital left-sided heart lesions (maternal effect) ( 25138779) Heel bone mineral density ( 30598549) Height ( 25429064 31562340) Multiple sclerosis ( 31604244 21833088) Physiological traits ( 31902109) Pulse pressure ( 27841878) Response to fenofibrate (triglyceride levels) ( 27002377) Rheumatoid arthritis ( 30423114 24390342)	Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 30224653 29403010 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)
Interacting Genes		68 interacting genes: ACOT7 BACH2 BANP BBC3 BYSL CDCA7L CDK18 CEP19 CYSRT1 DMRT3 DPH3 ESRRG FARS2 FRS3 FXR1 GOLGA2 GOLGA6L9 HAPLN2 KCTD7 KRT40 KRTAP10-1 LGALS14 MAGOHB MCC MDFI MID2 MORF4L1 MORN3 MRPL11 MTUS2 MYLIP MYO15B NEK6 NXF1 PIBF1 PICK1 PIH1D2 PLEKHN1 PNMA1 PRMT7 PSMB1 RABEP1 RECK RPP25 SCNM1 SET SMARCD1 SPANXN2 SSX2IP SUV39H1 SYT17 TBC1D22B TP53BP2 TRAF2 TRAPPC2 TRAPPC2B TRIM50 TSGA10 TSTD2 YES1 ZBTB8A ZNF143 ZNF17 ZNF202 ZNF526 ZNF629 ZNF648 ZRANB1	98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GAS8 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE PXN RASA1 RPL10 SH3GLB2 SKAP2 SLC9A3R1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B
Entrez ID		220929	7525
HPRD ID		11247	01285
Ensembl ID		ENSG00000183621	ENSG00000176105
Uniprot IDs		Q5T427 Q7Z4V0	P07947
PDB IDs			2HDA
Enriched GO Terms of Interacting Partners?
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