WDR5 and SRRM4

Data Source:
BioGRID (two hybrid)

		WDR5	SRRM4
Description		WD repeat domain 5	serine/arginine repetitive matrix 4
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus
	Molecular Function	Protein Binding Methylated Histone Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific)	MRNA Binding Protein Binding Identical Protein Binding
	Biological Process	Skeletal System Development Neuron Projection Development Post-translational Protein Modification Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Gluconeogenesis Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K4 Methylation	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development Sensory Perception Of Sound RNA Splicing Cell Differentiation Neuron Maturation Regulation Of RNA Splicing
Pathways		PKMTs methylate histone lysines HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Intraocular pressure ( 30591961)	Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Facial morphology (factor 3, length of philtrum) ( 28441456) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Photic sneeze reflex ( 27182965) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)
Interacting Genes		37 interacting genes: ANAPC2 APP ASH2L ATN1 BBC3 BHLHE41 CHD8 FAM199X H1-2 H3-4 H3C1 H4-16 HSF2 IKBKG KANSL1 KANSL2 KMT2A MARF1 MBIP MDM4 MEOX2 MLLT1 NR2E3 PDE9A POU5F1 PRMT5 PRNP RBBP5 RUSC1-AS1 SRPK2 SRRM4 SSX2IP TERF2IP TP53 WWP2 ZBTB48 ZXDC	30 interacting genes: AKAP17A ARL6IP4 C16orf87 C1orf35 CACNA1A CDC37 CLK1 CLK4 FAM9B LUC7L2 LUZP4 MCRS1 RBM25 RBM39 RBMX2 RNPS1 RSRC1 SNIP1 SNRNP70 SRRM1 SRSF11 TBC1D26 U2AF1 U2AF1L5 WDR5 ZNF124 ZNF286A ZNF699 ZRSR2 ZRSR2P1
Entrez ID		11091	84530
HPRD ID		10614	13897
Ensembl ID		ENSG00000196363	ENSG00000139767
Uniprot IDs		P61964	A7MD48 V5T9A0
PDB IDs		2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4CY1 4CY2 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4GM9 4GMB 4IA9 4O45 4QL1 4Y7R 5EAL 5EAM 5EAP 5EAR 5M23 5M25 5SXM 5VFC 6BYN 6D9X 6DAI 6DAK 6DAR 6DAS 6DY7 6DYA 6E1Y 6E1Z 6E22 6E23 6IAM 6KIU 6KIV 6KIW 6KIX 6KIZ 6OFZ 6OI0 6OI1 6OI2 6OI3 6PG3 6PG4 6PG5 6PG6 6PG7 6PG8 6PG9 6PGA 6PGB 6PGC 6PGD 6PGE 6PGF 6PWV 6PWW 6U5M 6U5Y 6U6W 6U80 6U8B 6U8L 6U8O 6UCS 6UFX 6UHY 6UHZ 6UIF 6UIK 6UJ4 6UJH 6UJJ 6UJL 6UOZ
Enriched GO Terms of Interacting Partners?
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