PRKG2 and MYLK

Data Source:
HPRD (in vitro)

		PRKG2	MYLK
Description		protein kinase cGMP-dependent 2	myosin light chain kinase
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GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane	Stress Fiber Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Lamellipodium Cleavage Furrow
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding	Actin Binding Protein Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport	Protein Phosphorylation Muscle Contraction Smooth Muscle Contraction Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing	Smooth Muscle Contraction RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs		Fostamatinib	Fostamatinib
Diseases			Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 28552196 25282103 19343178 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	General cognitive ability ( 29844566)
Interacting Genes		7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77	15 interacting genes: ACTA1 ACTC1 APPBP2 CALM1 CAMK2G CTTN GOPC HSPB1 MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC
Entrez ID		5593	4638
HPRD ID		09034	02952
Ensembl ID		ENSG00000138669	ENSG00000065534
Uniprot IDs		A0A140VJM3 B4DLF9 B7ZA25 Q13237	Q05B97 Q05B98 Q15746
PDB IDs		5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8	2CQV 2K0F 2YR3 5JQA 5JTH 6C6M
Enriched GO Terms of Interacting Partners?
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