LATS2 and TAZ

Data Source:
BioGRID (enzymatic study)

		LATS2	TAZ
Description		large tumor suppressor kinase 2	tafazzin
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytosol Centriolar Satellite	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	Muscle Contraction Inner Mitochondrial Membrane Organization Heart Development Skeletal Muscle Tissue Development Hemopoiesis Cardiolipin Biosynthetic Process Mitochondrial Respiratory Chain Complex I Assembly Cardiolipin Acyl-chain Remodeling Cristae Formation Mitochondrial ATP Synthesis Coupled Electron Transport Cardiac Muscle Tissue Development Cardiac Muscle Contraction
Pathways		Signaling by Hippo	Mitochondrial protein import Mitochondrial protein import Acyl chain remodeling of CL
Drugs
Diseases			3-Methylglutaconic aciduria (MGCA) Barth syndrome (BTHS) Dilated cardiomyopathy (DCM)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Refractive error ( 32231278)
Interacting Genes		67 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NF2 NFIC PDGFRA RAF1 RASSF1 RELA SMAD2 SNAI1 STK11 STK3 SUZ12 TAZ TEAD2 TP53 TSC1 WWTR1 YWHAG YWHAZ	9 interacting genes: BTRC CHGB CSNK1E GSK3B LATS1 LATS2 RUNX1 SLC9A3R2 YWHAE
Entrez ID		26524	6901
HPRD ID		07277	02316
Ensembl ID		ENSG00000150457	ENSG00000102125
Uniprot IDs		A0A024RDM3 Q9NRM7	A0A0S2Z4E6 A0A0S2Z4F4 A0A0S2Z4K0 A0A0S2Z4K9 A0A494C0C5 A0A499FJ53 A6XNE1 Q16635
PDB IDs		4ZRI
Enriched GO Terms of Interacting Partners?
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