RNF169 and H2AC18

Data Source:
BioGRID (pull down)

		RNF169	H2AC18
Description		ring finger protein 169	H2A clustered histone 18
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body Site Of Double-strand Break	Nucleosome Nucleus Extracellular Exosome
	Molecular Function	Protein Binding Transferase Activity Nucleosome Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Molecular_function DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Cellular Response To DNA Damage Stimulus Protein Ubiquitination Negative Regulation Of Double-strand Break Repair	Chromatin Silencing Biological_process
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS
Interacting Genes		10 interacting genes: CEP70 DYRK1A GOLGA2 H2AC18 H2AZ1 HOOK2 HSF2BP PIBF1 UBC UBE2E1	20 interacting genes: APP BAP1 BMI1 DNAJC2 H2BC15 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF168 RNF169 RNF2 RNF20 TBL1X UBC UBE2H USP16 USP21
Entrez ID		254225	8337
HPRD ID		19383	08851
Ensembl ID		ENSG00000166439	ENSG00000203812
Uniprot IDs		Q8NCN4	Q6FI13
PDB IDs		5GG4 5VEY	6SE6 6SEE 6SEF 6SEG 6Y5D
Enriched GO Terms of Interacting Partners?
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