RNF169 and H2AZ1

Data Source:
BioGRID (pull down)

		RNF169	H2AZ1
Description		ring finger protein 169	H2A.Z variant histone 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body Site Of Double-strand Break	Nucleosome Euchromatin Heterochromatin Barr Body Nucleus Extracellular Exosome
	Molecular Function	Protein Binding Transferase Activity Nucleosome Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Cellular Response To DNA Damage Stimulus Protein Ubiquitination Negative Regulation Of Double-strand Break Repair	Chromatin Silencing Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS
Interacting Genes		10 interacting genes: CEP70 DYRK1A GOLGA2 H2AC18 H2AZ1 HOOK2 HSF2BP PIBF1 UBC UBE2E1	7 interacting genes: FH INCENP MAGEC1 NCAPH RNF168 RNF169 USP16
Entrez ID		254225	3015
HPRD ID		19383	00823
Ensembl ID		ENSG00000166439	ENSG00000164032
Uniprot IDs		Q8NCN4	P0C0S5
PDB IDs		5GG4 5VEY	1F66 3WA9 4CAY 4NFT 5B31 5B32 5B33 5CHL 5FUG 5Z30 6JOU 6KO2
Enriched GO Terms of Interacting Partners?
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