FYN and CASP8

Data Source:
HPRD (in vitro)

		FYN	CASP8
Description		FYN proto-oncogene, Src family tyrosine kinase	caspase 8
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GO Annotations	Cellular Component	Nucleus Mitochondrion Endosome Cytosol Actin Filament Plasma Membrane Postsynaptic Density Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Neuron Projection Cell Body Membrane Raft Ripoptosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Alpha-tubulin Binding Phosphatidylinositol 3-kinase Binding Ion Channel Binding Metal Ion Binding Ephrin Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Peptide Hormone Receptor Binding Growth Factor Receptor Binding Disordered Domain Specific Binding	Cysteine-type Endopeptidase Activity Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Scaffold Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	MAPK Cascade Response To Singlet Oxygen Neuron Migration Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Heart Process Protein Phosphorylation Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Blood Coagulation Learning Feeding Behavior Regulation Of Cell Shape Negative Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Activation Forebrain Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Protein Catabolic Process Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Hydrogen Peroxide Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Ethanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Defense Response To Virus By Virus Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Leukocyte Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Protein Kinase B Signaling Cellular Response To Peptide Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Nucleus Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Death Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Response To Amyloid-beta Cellular Response To Amyloid-beta Cellular Response To L-glutamate Cellular Response To Glycine Positive Regulation Of Protein Localization To Membrane Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Heart Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Cold Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Natural Killer Cell Activation Macrophage Differentiation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Toll-like Receptor 3 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Suppression By Virus Of Host Cysteine-type Endopeptidase Activity Involved In Apoptotic Process T Cell Activation B Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Response To Antibiotic Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Pyroptosis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Death-inducing Signaling Complex Assembly Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Self Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		GPVI-mediated activation cascade Signaling by ERBB2 PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling VEGFA-VEGFR2 Pathway Dectin-2 family CD209 (DC-SIGN) signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Platelet Adhesion to exposed collagen Reelin signalling pathway Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Microbial modulation of RIPK1-mediated regulated necrosis Defective RIPK1-mediated regulated necrosis
Drugs		Dasatinib Triglyme Fostamatinib	Bryostatin 1 Bardoxolone
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anger ( 24489884) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Macular thickness ( 30535121) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Parkinson's disease ( 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 30285260) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908)	Basal cell carcinoma ( 28177523 25855136) Breast cancer ( 29059683) Chronic lymphocytic leukemia ( 28165464 26956414 23770605) Cutaneous malignant melanoma ( 32341527) Esophageal squamous cell carcinoma ( 25129146) Lymphocyte counts ( 27863252) Melanoma ( 21983787 28212542) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-small cell lung cancer ( 31326317) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Rheumatoid arthritis ( 30423114 24390342) White blood cell count ( 32888494)
Interacting Genes		198 interacting genes: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BAG4 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DLGAP4 DOK1 DOK3 DOK4 DTX3 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 ERRFI1 EVL FAM90A1 FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB1 GAB3 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B HNRNPK HRAS HSP90AA1 HTR6 IGHA1 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCK LCP2 MAG MAP2 MAPT MCAM MED28 MEOX2 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NOS1AP NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PRMT8 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RACK1 RAF1 RPL10 RPS6KA3 RPS6KB2 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TAMALIN TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRIM55 TRIM63 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70	132 interacting genes: AGR3 ANGPTL4 AP1M1 APAF1 APP AR ATAD2 ATG4D ATP1A3 BAP1 BCAP31 BCL2 BCL2L1 BCL2L10 BEX1 BFAR BID BIRC6 BLID BRD1 CASC3 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CCNL1 CDH1 CDH13 CDK11B CDKN1B CFLAR CHD3 CHUK CNBP COPS6 CRADD CTNNB1 DEDD DEDD2 EDA2R EIF2AK2 EPSTI1 ERRFI1 FADD FAF1 FAS FYN GLCE GMEB1 GREB1 GRIA1 GZMB HBP1 HDAC7 HECTD3 HIP1 IKBKB IKBKG IL13RA2 IL24 ILK KLK5 KLK9 KRT18 LYPD3 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 NSD3 PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PIK3C3 PLA2G4B PLEC PLIN4 PRDM14 PRDX6 PRKCI PRKCZ PRKN PRSS50 PSEN1 PSEN2 PSMC3IP QDPR RALBP1 RB1 RIPK1 RIPK2 RYBP S100A14 SCGB2A2 SERPINB5 SNRPD3 SOX2 SRC SRF ST14 STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 TRAF6 UBC UMPS USO1 VIM VPS45 YBX1 ZNF707
Entrez ID		2534	841
HPRD ID		00655	03459
Ensembl ID		ENSG00000010810	ENSG00000064012
Uniprot IDs		P06241	A0A024R3Z8 Q14790
PDB IDs		1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 2MQI 2MRJ 2MRK 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P 4ZNX 5ZAU 6EDF 6IPY 6IPZ	1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7 4PRZ 4PS1 4ZBW 5H31 5H33 5JQE 5L08 6AGW 6PX9
Enriched GO Terms of Interacting Partners?
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