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FYN and FAM90A1
Data Source:
BioGRID
(two hybrid)
FYN
FAM90A1
Description
FYN proto-oncogene, Src family tyrosine kinase
family with sequence similarity 90 member A1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Endosome
Cytosol
Actin Filament
Plasma Membrane
Postsynaptic Density
Dendrite
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum
Glial Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Enzyme Binding
Type 5 Metabotropic Glutamate Receptor Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Alpha-tubulin Binding
Phosphatidylinositol 3-kinase Binding
Ion Channel Binding
Metal Ion Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Peptide Hormone Receptor Binding
Growth Factor Receptor Binding
Disordered Domain Specific Binding
Protein Binding
Biological Process
MAPK Cascade
Response To Singlet Oxygen
Neuron Migration
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Heart Process
Protein Phosphorylation
Calcium Ion Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Axon Guidance
Blood Coagulation
Learning
Feeding Behavior
Regulation Of Cell Shape
Negative Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Activation
Forebrain Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Protein Catabolic Process
Response To Drug
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Hydrogen Peroxide
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Response To Ethanol
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendrite Morphogenesis
Regulation Of Defense Response To Virus By Virus
Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Protein Targeting To Membrane
Dendritic Spine Maintenance
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Glutamate Receptor Signaling Pathway
Positive Regulation Of Neuron Death
Negative Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Oxidative Stress-induced Cell Death
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Cellular Response To L-glutamate
Cellular Response To Glycine
Positive Regulation Of Protein Localization To Membrane
Regulation Of Calcium Ion Import Across Plasma Membrane
Positive Regulation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
GPVI-mediated activation cascade
Signaling by ERBB2
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Nephrin family interactions
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Platelet Adhesion to exposed collagen
Reelin signalling pathway
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Dasatinib
Triglyme
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Anger (
24489884
)
Autoimmune thyroid disease (
32581359
)
Bipolar disorder (
31043756
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
23128233
)
Intraocular pressure (
29617998
)
Macular thickness (
30535121
)
NASH resolution in nonalcoholic steatohepatitis (
31832568
)
Parkinson's disease (
32201043
32310270
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Schizophrenia (
28991256
30285260
)
Systolic blood pressure (
30578418
)
Ulcerative colitis (
28067908
)
Gut microbiota (functional units) (
27694959
)
Interacting Genes
198 interacting genes:
ACP1
ADAM15
ADD2
ARHGAP32
ARHGAP33
ATXN1
BAG4
BCAR1
BCL3
BTK
C7orf25
C8orf33
CASP3
CASP8
CAV1
CBL
CBLB
CBLC
CD19
CD2
CD226
CD247
CD2AP
CD36
CD44
CD48
CD5
CD55
CD79A
CD79B
CDH1
CDK1
CDK5
CLTC
CMA1
CNN1
CNN3
CNTN1
CNTNAP1
CRK
CSF1R
CSF2RB
CSK
CTLA4
CTNNB1
CTNND2
DAG1
DLG4
DLGAP4
DOK1
DOK3
DOK4
DTX3
EFS
ENO1
EPHA3
EPHA4
EPHA8
EPHB3
ERRFI1
EVL
FAM90A1
FAS
FASLG
FCER2
FCGR2A
FLOT1
FLOT2
FLT1
FNBP4
FYB1
GAB3
GP6
GRAP
GRB10
GRB2
GRIN1
GRIN2A
GRIN2B
HNRNPK
HRAS
HSP90AA1
HTR6
IGHA1
IL1B
IL2RB
IL7R
IRS1
ITCH
ITGB4
ITK
ITPR1
JAK2
JUP
KDM1A
KDR
KHDRBS1
KIT
LAT
LCK
LCP2
MAG
MAP2
MAPT
MCAM
MED28
MEOX2
MS4A1
NCAM1
NEDD4
NEDD9
NMT1
NOS1AP
NPHS1
NR3C1
NTRK2
PAG1
PAK2
PDE4D
PDGFRB
PECAM1
PIK3R1
PIK3R2
PIK3R3
PLAUR
PLCG1
PLCG2
PLD2
PRKCD
PRKCE
PRKCH
PRKCQ
PRKCZ
PRMT6
PRMT8
PTK2
PTK2B
PTPN11
PTPN5
PTPRA
PTPRC
PTPRE
PTPRF
PTPRZ1
PXN
RACK1
RAF1
RPL10
RPS6KA3
RPS6KB2
SDC3
SH2B2
SH2D1A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SLAMF1
SNCA
SOCS1
SOS1
SPHK1
SPHK2
SPN
STAT1
STAT3
SUV39H1
SYK
TAMALIN
TCAP
THY1
TNF
TNK2
TNNT1
TOM1L1
TRAF6
TRAT1
TRIM55
TRIM63
TRPC6
TRPV4
TUBA1B
TUBA3C
TUBA4A
TXK
TYK2
TYRO3
UHRF2
UNC119
VAV1
VAV2
WAS
WASF1
WASF2
WBP11
YTHDC1
ZAP70
162 interacting genes:
ABI2
ACTN3
AKAP9
AMOTL2
ANKRD23
ANKRD29
AP2M1
APP
ARHGEF9
ARRDC3
BANP
BCAR1
BEGAIN
BHLHB9
BLZF1
CADPS
CALCOCO2
CARD9
CCDC13
CCDC57
CCN3
CCNC
CCNL2
CDR2
CEP55
CEP70
CEP72
CEP76
CHRDL2
COG6
CYSRT1
DTX3
DVL2
DVL3
EFEMP2
ENKD1
EXOSC8
FAM228A
FHL3
FLACC1
FLOT1
FOSB
FSD2
FXR1
FXR2
FYN
GABPB1
GCSAML
GNPTAB
GOLGA2
GOPC
GPSM1
GRIPAP1
HAND2
HMBOX1
HOMER3
HOMEZ
HOOK2
HSF2BP
ISY1
KANK2
KASH5
KIFC3
KLHL12
KPNA3
KPNA6
KRT31
KRT34
KRT38
KRT40
KRTAP1-1
KRTAP10-8
LDOC1
LHX6
LIMS1
LMO2
LNX1
LRP2BP
LRRK2
LZTS1
LZTS2
MAD1L1
MDFI
MEIS3
MID2
MIPOL1
MLH1
MORN3
MSS51
MTUS2
MYOG
NBPF19
NDUFB7
NOTCH2NLA
NUDT21
OVOL1
PBX1
PBX2
PDLIM7
PFDN5
PICK1
PIH1D1
PLAGL2
POF1B
PPARA
PPP1R13B
PRDM6
PRKAR1B
PRR23B
PSME3
PSTPIP1
RAB11FIP2
RABEP1
RBM48
REL
RHOH
RINT1
ROPN1
RPRD1A
SH2B2
SIAH1
SMAD3
SMARCB1
SNW1
SPRED1
SRPK2
STAC3
STMN2
STX11
TAX1BP1
TEPSIN
TFIP11
TLE5
TMCC2
TRAF2
TRAF4
TRIB3
TRIM23
TRIM27
TRIM42
TRIM54
TRIM55
TRIM69
TRIM9
TRIML2
VRTN
VWC2
ZBTB14
ZBTB16
ZBTB7B
ZBTB8A
ZC2HC1C
ZMYND12
ZNF143
ZNF212
ZNF343
ZNF526
ZNF581
ZNF655
ZNF688
ZNF76
ZWINT
Entrez ID
2534
55138
HPRD ID
00655
07672
Ensembl ID
ENSG00000010810
ENSG00000171847
Uniprot IDs
P06241
Q86YD7
PDB IDs
1A0N
1AOT
1AOU
1AVZ
1AZG
1EFN
1FYN
1G83
1M27
1NYF
1NYG
1SHF
1ZBJ
2DQ7
2MQI
2MRJ
2MRK
3H0F
3H0H
3H0I
3UA6
3UA7
4D8D
4EIK
4U17
4U1P
4ZNX
5ZAU
6EDF
6IPY
6IPZ
Enriched GO Terms of Interacting Partners
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