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CASP8 and VIM
Data Source:
BioGRID
(two hybrid)
HPRD
(in vivo)
CASP8
VIM
Description
caspase 8
vimentin
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Cytoskeleton
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Protein-containing Complex
Neuron Projection
Cell Body
Membrane Raft
Ripoptosome
Cytoplasm
Peroxisome
Cytosol
Polysome
Cytoskeleton
Intermediate Filament
Plasma Membrane
Focal Adhesion
Nuclear Matrix
Cell Leading Edge
Neuron Projection
Intermediate Filament Cytoskeleton
Phagocytic Vesicle
Extracellular Exosome
Ribonucleoprotein Complex
Molecular Function
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Scaffold Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Double-stranded RNA Binding
Structural Constituent Of Cytoskeleton
Structural Constituent Of Eye Lens
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Scaffold Protein Binding
Keratin Filament Binding
Biological Process
Angiogenesis
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Surface Receptor Signaling Pathway
Heart Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Response To Cold
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Natural Killer Cell Activation
Macrophage Differentiation
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Beta Production
Toll-like Receptor 3 Signaling Pathway
Response To Tumor Necrosis Factor
TRIF-dependent Toll-like Receptor Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Suppression By Virus Of Host Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
T Cell Activation
B Cell Activation
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Response To Antibiotic
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Pyroptosis
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Cyclic Compound
Death-inducing Signaling Complex Assembly
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Activation Of Cysteine-type Endopeptidase Activity
Self Proteolysis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Neuron Projection Development
Astrocyte Development
Viral Process
Cytokine-mediated Signaling Pathway
Muscle Filament Sliding
Positive Regulation Of Collagen Biosynthetic Process
Regulation Of MRNA Stability
Intermediate Filament Organization
Positive Regulation Of Translation
Bergmann Glial Cell Differentiation
SMAD Protein Signal Transduction
Lens Fiber Cell Development
Cellular Response To Lipopolysaccharide
Cellular Response To Muramyl Dipeptide
Cellular Response To Interferon-gamma
Pathways
Apoptotic cleavage of cellular proteins
Caspase activation via Death Receptors in the presence of ligand
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Microbial modulation of RIPK1-mediated regulated necrosis
Defective RIPK1-mediated regulated necrosis
Caspase-mediated cleavage of cytoskeletal proteins
Striated Muscle Contraction
Interleukin-4 and Interleukin-13 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Drugs
Bryostatin 1
Bardoxolone
Artenimol
Phenethyl Isothiocyanate
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Basal cell carcinoma (
28177523
25855136
)
Breast cancer (
29059683
)
Chronic lymphocytic leukemia (
28165464
26956414
23770605
)
Cutaneous malignant melanoma (
32341527
)
Esophageal squamous cell carcinoma (
25129146
)
Lymphocyte counts (
27863252
)
Melanoma (
21983787
28212542
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Non-small cell lung cancer (
31326317
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
)
Rheumatoid arthritis (
30423114
24390342
)
White blood cell count (
32888494
)
Cholesterol, total (
24097068
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Total cholesterol levels (
28334899
)
Triglyceride levels (
32203549
)
Interacting Genes
132 interacting genes:
AGR3
ANGPTL4
AP1M1
APAF1
APP
AR
ATAD2
ATG4D
ATP1A3
BAP1
BCAP31
BCL2
BCL2L1
BCL2L10
BEX1
BFAR
BID
BIRC6
BLID
BRD1
CASC3
CASP1
CASP10
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8AP2
CASP9
CCNL1
CDH1
CDH13
CDK11B
CDKN1B
CFLAR
CHD3
CHUK
CNBP
COPS6
CRADD
CTNNB1
DEDD
DEDD2
EDA2R
EIF2AK2
EPSTI1
ERRFI1
FADD
FAF1
FAS
FYN
GLCE
GMEB1
GREB1
GRIA1
GZMB
HBP1
HDAC7
HECTD3
HIP1
IKBKB
IKBKG
IL13RA2
IL24
ILK
KLK5
KLK9
KRT18
LYPD3
MAP1LC3B
MAP3K14
MAP4K4
MAPK1
MAPK3
MAPT
NOD1
NOL3
NR1H4
NSD3
PARK7
PARP1
PARP2
PCYT1A
PDIA6
PEA15
PIAS1
PICALM
PIK3C3
PLA2G4B
PLEC
PLIN4
PRDM14
PRDX6
PRKCI
PRKCZ
PRKN
PRSS50
PSEN1
PSEN2
PSMC3IP
QDPR
RALBP1
RB1
RIPK1
RIPK2
RYBP
S100A14
SCGB2A2
SERPINB5
SNRPD3
SOX2
SRC
SRF
ST14
STK24
SUMO1
TFCP2
TNFRSF10A
TNFRSF10B
TOPORS
TRAF1
TRAF2
TRAF6
UBC
UMPS
USO1
VIM
VPS45
YBX1
ZNF707
171 interacting genes:
ABLIM1
AKT1
ANKRD35
ANXA7
APIP
APLP1
APP
ARMC7
ARMCX2
ATN1
BFSP1
BHLHE40
BRD1
BYSL
C2CD6
CAMK2D
CAPN1
CASP3
CASP6
CASP7
CASP8
CASP9
CBX8
CCDC187
CDH5
CDK1
CDKN1A
CEP126
CHD3
COPS6
CRCT1
CREB1
CRMP1
CT55
CWF19L2
DCTN1
DEFB1
DES
DIS3L2
DNM1L
DPPA4
DSP
DUX4
DYNLL1
ENTR1
ESS2
FABP4
FAM107A
FAM118B
FAM161A
FUBP1
GADD45A
GEM
GFAP
GOPC
GRB2
GSK3B
HABP4
HAP1
HMG20B
HSPB1
HTRA2
ING5
IP6K1
ITGB4
IVNS1ABP
KARS1
KAT7
KIAA0408
KIF15
KIF9
KIFC3
KRT20
KRT75
LGALS14
LINC01554
LORICRIN
LRIF1
MAFG
MAN2A2
MCPH1
MEN1
MICAL1
MRPL44
MTDH
NEFL
NEFM
NFATC2
NFKBID
NIF3L1
NME2
NOC4L
NR1H2
NUP85
OSBP2
PAK2
PDLIM1
PIAS4
PKD1
PKN1
PKP1
PLA2G2A
PLA2G4A
PLEC
PNMA5
POLR1C
PPHLN1
PPL
PPP1R18
PRKACA
PRPH
PSMA1
PSMC5
PSMD7
PSME1
PUF60
RAB8B
RABAC1
RAD51
RBM48
RIBC2
ROCK1
RPA1
SCNM1
SERBP1
SETDB1
SH3GL1
SH3GL3
SH3YL1
SIRPA
SIRT6
SLC25A6
SLC27A6
SMAD3
SMARCB1
SRRT
STK19
STX1A
SUMO2
SUMO3
SYN1
TAB2
TCEA2
TCHP
TLE5
TNFRSF14
TNNT1
TRIM14
TRIM15
TRIM28
TRIM29
TRIOBP
TSC22D1
TTR
TUBA1C
TUBGCP4
TXLNB
TXN
TXN2
UPP1
UPP2
UROD
UTP14A
WBP11
XRCC4
YAE1
YWHAE
YWHAZ
ZHX1
ZNF384
ZNF572
Entrez ID
841
7431
HPRD ID
03459
01899
Ensembl ID
ENSG00000064012
ENSG00000026025
Uniprot IDs
A0A024R3Z8
Q14790
P08670
V9HWE1
PDB IDs
1F9E
1I4E
1QDU
1QTN
2C2Z
2FUN
2K7Z
2Y1L
3H11
3KJN
3KJQ
4JJ7
4PRZ
4PS1
4ZBW
5H31
5H33
5JQE
5L08
6AGW
6PX9
1GK4
1GK6
1GK7
3G1E
3KLT
3S4R
3SSU
3SWK
3TRT
3UF1
4MCY
4MCZ
4MD0
4MD5
4MDI
4MDJ
4YPC
4YV3
5WHF
6ATF
6ATI
6BIR
Enriched GO Terms of Interacting Partners
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