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CASP8 and NR1H4
Data Source:
HPRD
(in vitro)
CASP8
NR1H4
Description
caspase 8
nuclear receptor subfamily 1 group H member 4
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Cytoskeleton
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Protein-containing Complex
Neuron Projection
Cell Body
Membrane Raft
Ripoptosome
Chromatin
Euchromatin
Nucleoplasm
Receptor Complex
Molecular Function
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Scaffold Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Nuclear Receptor Binding
Bile Acid Binding
Bile Acid Receptor Activity
Sequence-specific DNA Binding
Retinoid X Receptor Binding
Chenodeoxycholic Acid Binding
Biological Process
Angiogenesis
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Surface Receptor Signaling Pathway
Heart Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Response To Cold
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Natural Killer Cell Activation
Macrophage Differentiation
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Beta Production
Toll-like Receptor 3 Signaling Pathway
Response To Tumor Necrosis Factor
TRIF-dependent Toll-like Receptor Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Suppression By Virus Of Host Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
T Cell Activation
B Cell Activation
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Response To Antibiotic
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Pyroptosis
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Cyclic Compound
Death-inducing Signaling Complex Assembly
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Activation Of Cysteine-type Endopeptidase Activity
Self Proteolysis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Transcription By RNA Polymerase II
Nitrogen Catabolite Activation Of Transcription From RNA Polymerase II Promoter
Cellular Glucose Homeostasis
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Inflammatory Response
Cell-cell Junction Assembly
Notch Signaling Pathway
Bile Acid Metabolic Process
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling
Regulation Of Low-density Lipoprotein Particle Clearance
Bile Acid And Bile Salt Transport
Cell Differentiation
Intracellular Receptor Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Interleukin-17 Production
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-1 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Regulation Of Urea Metabolic Process
Histone H3-R17 Methylation
Cellular Triglyceride Homeostasis
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Bile Acid Signaling Pathway
Intracellular Bile Acid Receptor Signaling Pathway
Cholesterol Homeostasis
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Fatty Acid Homeostasis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Bile Acid Biosynthetic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Fatty Acid
Cellular Response To Organonitrogen Compound
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Cholesterol Metabolic Process
Cellular Response To Bile Acid
Positive Regulation Of Adipose Tissue Development
Positive Regulation Of Phosphatidic Acid Biosynthetic Process
Positive Regulation Of Glutamate Metabolic Process
Positive Regulation Of Ammonia Assimilation Cycle
Pathways
Apoptotic cleavage of cellular proteins
Caspase activation via Death Receptors in the presence of ligand
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Microbial modulation of RIPK1-mediated regulated necrosis
Defective RIPK1-mediated regulated necrosis
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
Endogenous sterols
Drugs
Bryostatin 1
Bardoxolone
alpha-Linolenic acid
Ursodeoxycholic acid
Farnesol
Fexaramine
Cholic Acid
Deoxycholic acid
Taurocholic acid
Arachidonic Acid
Obeticholic acid
Chenodeoxycholic acid
(8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid
Myrrh
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Basal cell carcinoma (
28177523
25855136
)
Breast cancer (
29059683
)
Chronic lymphocytic leukemia (
28165464
26956414
23770605
)
Cutaneous malignant melanoma (
32341527
)
Esophageal squamous cell carcinoma (
25129146
)
Lymphocyte counts (
27863252
)
Melanoma (
21983787
28212542
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Non-small cell lung cancer (
31326317
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
)
Rheumatoid arthritis (
30423114
24390342
)
White blood cell count (
32888494
)
Low density lipoprotein cholesterol levels (
29403010
)
Squamous cell carcinoma (
23341777
)
Interacting Genes
132 interacting genes:
AGR3
ANGPTL4
AP1M1
APAF1
APP
AR
ATAD2
ATG4D
ATP1A3
BAP1
BCAP31
BCL2
BCL2L1
BCL2L10
BEX1
BFAR
BID
BIRC6
BLID
BRD1
CASC3
CASP1
CASP10
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8AP2
CASP9
CCNL1
CDH1
CDH13
CDK11B
CDKN1B
CFLAR
CHD3
CHUK
CNBP
COPS6
CRADD
CTNNB1
DEDD
DEDD2
EDA2R
EIF2AK2
EPSTI1
ERRFI1
FADD
FAF1
FAS
FYN
GLCE
GMEB1
GREB1
GRIA1
GZMB
HBP1
HDAC7
HECTD3
HIP1
IKBKB
IKBKG
IL13RA2
IL24
ILK
KLK5
KLK9
KRT18
LYPD3
MAP1LC3B
MAP3K14
MAP4K4
MAPK1
MAPK3
MAPT
NOD1
NOL3
NR1H4
NSD3
PARK7
PARP1
PARP2
PCYT1A
PDIA6
PEA15
PIAS1
PICALM
PIK3C3
PLA2G4B
PLEC
PLIN4
PRDM14
PRDX6
PRKCI
PRKCZ
PRKN
PRSS50
PSEN1
PSEN2
PSMC3IP
QDPR
RALBP1
RB1
RIPK1
RIPK2
RYBP
S100A14
SCGB2A2
SERPINB5
SNRPD3
SOX2
SRC
SRF
ST14
STK24
SUMO1
TFCP2
TNFRSF10A
TNFRSF10B
TOPORS
TRAF1
TRAF2
TRAF6
UBC
UMPS
USO1
VIM
VPS45
YBX1
ZNF707
15 interacting genes:
CASP8
EP300
ESR1
GAPDH
H3C1
NCOA1
NCOA6
NCOR2
PPARGC1A
RXRA
RXRB
RXRG
SIRT1
SMARCD1
SMARCD3
Entrez ID
841
9971
HPRD ID
03459
04827
Ensembl ID
ENSG00000064012
ENSG00000012504
Uniprot IDs
A0A024R3Z8
Q14790
B6ZGS9
F1DAL1
Q96RI1
PDB IDs
1F9E
1I4E
1QDU
1QTN
2C2Z
2FUN
2K7Z
2Y1L
3H11
3KJN
3KJQ
4JJ7
4PRZ
4PS1
4ZBW
5H31
5H33
5JQE
5L08
6AGW
6PX9
1OSH
1OSK
3BEJ
3DCT
3DCU
3FLI
3FXV
3GD2
3HC5
3HC6
3L1B
3OKH
3OKI
3OLF
3OMK
3OMM
3OOF
3OOK
3P88
3P89
3RUT
3RUU
3RVF
4OIV
4QE6
4QE8
4WVD
5IAW
5ICK
5Q0I
5Q0J
5Q0K
5Q0L
5Q0M
5Q0N
5Q0O
5Q0P
5Q0Q
5Q0R
5Q0S
5Q0T
5Q0U
5Q0V
5Q0W
5Q0X
5Q0Y
5Q0Z
5Q10
5Q11
5Q12
5Q13
5Q14
5Q15
5Q16
5Q17
5Q18
5Q19
5Q1A
5Q1B
5Q1C
5Q1D
5Q1E
5Q1F
5Q1G
5Q1H
5Q1I
5WZX
5Y1J
5Y44
5Y49
5YXB
5YXD
5YXJ
5YXL
5Z12
6A5W
6A5X
6A5Y
6A5Z
6A60
6HL0
6HL1
6ITM
Enriched GO Terms of Interacting Partners
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