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FYN and MEOX2
Data Source:
BioGRID
(two hybrid)
FYN
MEOX2
Description
FYN proto-oncogene, Src family tyrosine kinase
mesenchyme homeobox 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Endosome
Cytosol
Actin Filament
Plasma Membrane
Postsynaptic Density
Dendrite
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum
Glial Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Chromatin
Nucleus
Cytoplasm
Nuclear Speck
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Enzyme Binding
Type 5 Metabotropic Glutamate Receptor Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Alpha-tubulin Binding
Phosphatidylinositol 3-kinase Binding
Ion Channel Binding
Metal Ion Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Peptide Hormone Receptor Binding
Growth Factor Receptor Binding
Disordered Domain Specific Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
MAPK Cascade
Response To Singlet Oxygen
Neuron Migration
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Heart Process
Protein Phosphorylation
Calcium Ion Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Axon Guidance
Blood Coagulation
Learning
Feeding Behavior
Regulation Of Cell Shape
Negative Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Activation
Forebrain Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Protein Catabolic Process
Response To Drug
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Hydrogen Peroxide
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Response To Ethanol
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendrite Morphogenesis
Regulation Of Defense Response To Virus By Virus
Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Protein Targeting To Membrane
Dendritic Spine Maintenance
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Glutamate Receptor Signaling Pathway
Positive Regulation Of Neuron Death
Negative Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Oxidative Stress-induced Cell Death
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Cellular Response To L-glutamate
Cellular Response To Glycine
Positive Regulation Of Protein Localization To Membrane
Regulation Of Calcium Ion Import Across Plasma Membrane
Positive Regulation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Angiogenesis
Somite Specification
Regulation Of Transcription By RNA Polymerase II
Multicellular Organism Development
Skeletal Muscle Tissue Development
Blood Circulation
Positive Regulation Of Transcription By RNA Polymerase II
Roof Of Mouth Development
Limb Development
Somite Development
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways
GPVI-mediated activation cascade
Signaling by ERBB2
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Nephrin family interactions
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Platelet Adhesion to exposed collagen
Reelin signalling pathway
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Dasatinib
Triglyme
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Anger (
24489884
)
Autoimmune thyroid disease (
32581359
)
Bipolar disorder (
31043756
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
23128233
)
Intraocular pressure (
29617998
)
Macular thickness (
30535121
)
NASH resolution in nonalcoholic steatohepatitis (
31832568
)
Parkinson's disease (
32201043
32310270
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Schizophrenia (
28991256
30285260
)
Systolic blood pressure (
30578418
)
Ulcerative colitis (
28067908
)
Adolescent idiopathic scoliosis (
31417091
)
Blood trace element (Zn levels) (
23720494
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
28869591
)
HOMA-B (corrected for HOMA-IR) (
30369944
)
Kidney function decline traits (
25493955
)
Resting-state electroencephalogram vigilance (
29703947
)
Sweet taste preference (
32572145
)
Total intracranial volume (
31530798
)
Triglyceride levels (
32203549
)
Interacting Genes
198 interacting genes:
ACP1
ADAM15
ADD2
ARHGAP32
ARHGAP33
ATXN1
BAG4
BCAR1
BCL3
BTK
C7orf25
C8orf33
CASP3
CASP8
CAV1
CBL
CBLB
CBLC
CD19
CD2
CD226
CD247
CD2AP
CD36
CD44
CD48
CD5
CD55
CD79A
CD79B
CDH1
CDK1
CDK5
CLTC
CMA1
CNN1
CNN3
CNTN1
CNTNAP1
CRK
CSF1R
CSF2RB
CSK
CTLA4
CTNNB1
CTNND2
DAG1
DLG4
DLGAP4
DOK1
DOK3
DOK4
DTX3
EFS
ENO1
EPHA3
EPHA4
EPHA8
EPHB3
ERRFI1
EVL
FAM90A1
FAS
FASLG
FCER2
FCGR2A
FLOT1
FLOT2
FLT1
FNBP4
FYB1
GAB3
GP6
GRAP
GRB10
GRB2
GRIN1
GRIN2A
GRIN2B
HNRNPK
HRAS
HSP90AA1
HTR6
IGHA1
IL1B
IL2RB
IL7R
IRS1
ITCH
ITGB4
ITK
ITPR1
JAK2
JUP
KDM1A
KDR
KHDRBS1
KIT
LAT
LCK
LCP2
MAG
MAP2
MAPT
MCAM
MED28
MEOX2
MS4A1
NCAM1
NEDD4
NEDD9
NMT1
NOS1AP
NPHS1
NR3C1
NTRK2
PAG1
PAK2
PDE4D
PDGFRB
PECAM1
PIK3R1
PIK3R2
PIK3R3
PLAUR
PLCG1
PLCG2
PLD2
PRKCD
PRKCE
PRKCH
PRKCQ
PRKCZ
PRMT6
PRMT8
PTK2
PTK2B
PTPN11
PTPN5
PTPRA
PTPRC
PTPRE
PTPRF
PTPRZ1
PXN
RACK1
RAF1
RPL10
RPS6KA3
RPS6KB2
SDC3
SH2B2
SH2D1A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SLAMF1
SNCA
SOCS1
SOS1
SPHK1
SPHK2
SPN
STAT1
STAT3
SUV39H1
SYK
TAMALIN
TCAP
THY1
TNF
TNK2
TNNT1
TOM1L1
TRAF6
TRAT1
TRIM55
TRIM63
TRPC6
TRPV4
TUBA1B
TUBA3C
TUBA4A
TXK
TYK2
TYRO3
UHRF2
UNC119
VAV1
VAV2
WAS
WASF1
WASF2
WBP11
YTHDC1
ZAP70
686 interacting genes:
-
ABI2
ACBD4
ACOT12
ACSS1
ACTN4
ADAMTS12
ADGRF4
AGPAT1
AHCYL1
AHNAK
AHSA2P
AKT2
ALOX5
ALPP
AMMECR1
AMOT
ANKRD1
ANKRD12
ANKS1A
ANP32B
AP3M2
ARF6
ARHGEF7
ARIH2
ARL15
ARNT2
ARNTL2
ASB10
ATG12
ATG2A
ATG5
ATG9A
ATP5F1C
ATP6V0D2
ATP6V1C2
ATPSCKMT
ATXN1L
AXIN1
B4GALT2
BANP
BCL2L15
BEX1
BMP5
BNIP2
BOD1L2
BOLA2
BOLA2B
BTBD3
BTK
BTN1A1
BUD31
BYSL
C10orf120
C10orf88
C11orf68
C1orf109
C1orf174
C1orf50
C2orf76
C9orf64
CACNA1S
CAMK2B
CAPRIN2
CARD9
CASP14
CBX2
CCDC102B
CCDC103
CCDC13
CCDC196
CCDC6
CCL19
CCNC
CCNYL1
CDC34
CDC7
CDCA7L
CDH9
CDK3
CDK5
CDKN1A
CDKN2D
CEP57L1
CFAP206
CHD2
CHIC2
CHRD
CHRNB4
CHRNG
CHST15
CIAO1
CIAPIN1
CIB3
CINP
CKS1B
CLIC1
CLIP4
CLP1
CLVS2
CMTM5
CNTNAP2
COG7
COL9A2
COMP
COX7A2
CPNE2
CPNE6
CPNE7
CPSF4
CRCT1
CSDC2
CSF2
CSH2
CSNK2A1
CT55
CTNNBL1
CUTC
CXCL1
CXCL5
CXorf38
CXXC1
CYB5R2
CYCS
CYP4F12
CYSRT1
DCX
DEF8
DEFA5
DEPDC5
DESI1
DGCR6
DGCR8
DHPS
DIRAS3
DMRT3
DNAAF11
DNAJC17
DNAJC22
DNMT3A
DOCK8
DPF2
DPH3
DPM1
DRG1
DSCR8
DUS1L
DYNC2I2
DYNLL2
DYNLT5
E2F8
EDF1
EFEMP1
EFEMP2
EFNA3
EIF1AD
EIF3G
EIF4A3
EIF5A
EIF6
EMC7
EMD
EME2
EPM2AIP1
ERF
ESM1
ESR2
ESRRG
ETV4
EXOSC5
FAAP20
FAM126A
FAM13C
FAM219B
FAM221A
FAM3A
FAM53B
FAM53C
FAM71E2
FAM74A4
FANCC
FANCG
FBF1
FBLN1
FBLN5
FBXO39
FBXO44
FDX2
FGA
FKBP6
FOSL2
FOXR1
FTL
FUCA2
FUT11
FYN
GABRB3
GAGE1
GCM2
GINS3
GJC1
GLO1
GMCL2
GMPR2
GNG11
GNG13
GOLGA8DP
GOLGA8EP
GOLGA8F
GPANK1
GPATCH2L
GPKOW
GPSM3
GRIPAP1
GRN
GSDMD
GTPBP3
GUCD1
H1-7
HAT1
HDAC7
HDHD2
HELLS
HEXIM2
HGF
HK3
HLA-A
HLA-DPB1
HMBOX1
HMGB3
HNRNPC
HNRNPD
HOOK1
HOOK3
HORMAD1
HOXB5
HOXC8
HP1BP3
HSD3B7
HSPA2
HTR1E
IFIT2
IFNA14
IFNA6
IGF2BP3
IGFN1
IKZF1
IL1A
ILF2
INPP1
INPP5J
INSRR
INTS10
IP6K2
IP6K3
IQGAP1
IRX6
ITGB3BP
ITM2A
JAM3
JPH1
KANK2
KAT5
KATNAL1
KBTBD7
KCNIP4
KCTD7
KCTD9
KDM6A
KDM8
KIF5B
KIF5C
KIZ
KLC4
KLHL32
KLHL38
KPRP
KRT80
KRT81
KRT83
KRT86
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-2
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
KRTCAP3
KTN1
LAMTOR5
LARP1B
LAT
LCE1B
LCE1D
LCE1E
LCE2A
LCE4A
LCN15
LEMD1
LIN37
LIPF
LMO1
LNX1
LRRC18
LRRC27
LRRC52
LSM2
LUC7L2
LY6G6D
MAB21L2
MACO1
MAGED1
MALSU1
MAPKBP1
MAPRE1
MAPRE3
MBD3
MCM7
MDFI
METAP1
METTL17
METTL21A
MFF
MICOS10-NBL1
MID2
MKRN3
MLF1
MLLT6
MLX
MMP25
MMP3
MOAP1
MOBP
MORF4L1
MORF4L2
MORN3
MOS
MPP1
MRFAP1L1
MSI2
MT-CO1
MT-ND1
MT1DP
MTMR10
MVP
MYBPC1
MYL7
MYO5B
NAA10
NAA60
NALCN
NBL1
NCALD
NCK2
NCS1
NDUFA11
NDUFB2
NECTIN2
NEK6
NELL1
NFKBID
NFYB
NLGN3
NME7
NOL4
NOP10
NPIPB5
NR1D2
NSF
NTAN1
NTF3
NTN4
ODAD4
ODF1
ODF2
ODF2L
ODF4
OIT3
OLFM1
OLFM3
OR5K2
OR6B1
OSBPL1A
OSGIN1
OSTF1
P4HA3
PACSIN2
PAGE2
PAGE5
PAK1IP1
PAM16
PARP3
PARVG
PAX1
PAX3
PCDH9
PCSK5
PDE4C
PDHA2
PDP1
PDS5A
PELO
PGBD1
PHF1
PICK1
PIN1
PKIG
PLAC8
PLCB4
PLCD4
PMM2
PMS2
PNKP
PNLIPRP1
POLR1A
POLR1C
POLR3GL
POM121C
POMT1
PPP1CB
PPP1R18
PRAP1
PRKAB2
PRKAG1
PRKCI
PRKG1
PRKN
PRL
PRMT3
PRPF18
PRPF31
PRR19
PSMB10
PSMB8
PSMC1
PSMD14
PSMD9
PSME3
PTGER3
PWWP3A
PXT1
RAB11B
RAB2B
RAB41
RAB6B
RAD51B
RAD51D
RAD52
RAP1GAP2
RARB
RASAL2
RBM10
RBM5
RBPJL
RCHY1
RECK
RELA
RFTN2
RFX3
RGS5
RHOJ
RIMS3
RIPPLY1
RMND5A
RND2
RNF25
RNF40
RNF41
RNF6
RPL15
RPL23
RPP40
RPS4Y1
RRP8
RUNX1T1
RWDD2B
SAE1
SAMD4A
SAMM50
SAT1
SATB1
SCAF1
SCARF1
SCG5
SCIMP
SCNM1
SCRN2
SDCBP
SEC14L4
SEC63
SELENOP
SET
SFTPB
SH2D1B
SH2D4A
SHFL
SHISA3
SIRPB1
SKP1
SLC22A23
SLC23A1
SLC24A5
SLC25A17
SLC25A31
SLC27A5
SLC48A1
SLC66A1L
SLC9A8
SLIT1
SMAD3
SMARCE1
SMG6
SMYD1
SNRPF
SPANXN2
SPANXN3
SPATA1
SPEG
SPON1
SPP1
SPRED1
SPRY1
SPRY2
SPRY3
SPTY2D1
SRSF11
SSX3
STAC
STC1
STK11IP
STK16
STRA8
STX11
STX16
STX6
STXBP1
SUFU
SUSD4
SYNE2
SYT17
TAF1B
TASOR2
TBC1D21
TBCEL
TBL2
TBRG4
TBX6
TCEA2
TCEANC
TCL6
TDO2
TEX14
TEX47
TGFB1
THRA
TICAM2
TJAP1
TMEM100
TMEM14B
TMEM266
TMPRSS11E
TNPO3
TP53BP1
TPTE
TRAF5
TRAF6
TRAPPC2L
TRARG1
TRIM17
TRIM41
TRIM42
TRIM45
TRIM50
TRIML2
TRIP10
TRMT112
TRMT2A
TSGA10IP
TSPAN7
TSPO
TSR2
TSSK1B
TSTD2
TTC39B
TTC9C
TTLL10
TULP2
TXLNA
TXLNB
TXN2
TXNL4B
U2AF1
U2AF1L5
UBA2
UBE2D1
UBE2K
UBE3A
UBL4A
UBL4B
UBXN2B
UBXN8
UNC45A
UPP2
USE1
USP20
USP32
UTP14C
UTP23
UTP25
VAC14
VASN
VBP1
VCX2
VDR
VEZF1
VIP
VMP1
VPS26C
VWA5A
VWC2L
VWCE
WDR37
WDR5
WFDC13
WFDC5
WFDC6
WFDC9
XPA
XRCC2
YJU2
ZBED4
ZBED8
ZBTB16
ZBTB2
ZCWPW1
ZFP42
ZKSCAN3
ZKSCAN4
ZMAT2
ZMYND8
ZNF124
ZNF202
ZNF23
ZNF248
ZNF250
ZNF276
ZNF329
ZNF330
ZNF404
ZNF410
ZNF417
ZNF483
ZNF490
ZNF512B
ZNF556
ZNF564
ZNF572
ZNF574
ZNF587
ZNF648
ZNF688
ZNF69
ZNF695
ZNF772
ZNF92
Entrez ID
2534
4223
HPRD ID
00655
02760
Ensembl ID
ENSG00000010810
ENSG00000106511
Uniprot IDs
P06241
P50222
PDB IDs
1A0N
1AOT
1AOU
1AVZ
1AZG
1EFN
1FYN
1G83
1M27
1NYF
1NYG
1SHF
1ZBJ
2DQ7
2MQI
2MRJ
2MRK
3H0F
3H0H
3H0I
3UA6
3UA7
4D8D
4EIK
4U17
4U1P
4ZNX
5ZAU
6EDF
6IPY
6IPZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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