Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
FYN and SYK
Data Source:
HPRD
(in vivo, in vitro)
FYN
SYK
Description
FYN proto-oncogene, Src family tyrosine kinase
spleen associated tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Endosome
Cytosol
Actin Filament
Plasma Membrane
Postsynaptic Density
Dendrite
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum
Glial Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
B Cell Receptor Complex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Early Phagosome
Protein-containing Complex
T Cell Receptor Complex
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Enzyme Binding
Type 5 Metabotropic Glutamate Receptor Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Alpha-tubulin Binding
Phosphatidylinositol 3-kinase Binding
Ion Channel Binding
Metal Ion Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Peptide Hormone Receptor Binding
Growth Factor Receptor Binding
Disordered Domain Specific Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Interleukin-15 Receptor Binding
Protein Kinase Binding
Phosphatase Binding
Toll-like Receptor Binding
SH2 Domain Binding
Biological Process
MAPK Cascade
Response To Singlet Oxygen
Neuron Migration
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Heart Process
Protein Phosphorylation
Calcium Ion Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Axon Guidance
Blood Coagulation
Learning
Feeding Behavior
Regulation Of Cell Shape
Negative Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Activation
Forebrain Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Protein Catabolic Process
Response To Drug
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Hydrogen Peroxide
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Response To Ethanol
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendrite Morphogenesis
Regulation Of Defense Response To Virus By Virus
Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Protein Targeting To Membrane
Dendritic Spine Maintenance
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Glutamate Receptor Signaling Pathway
Positive Regulation Of Neuron Death
Negative Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Oxidative Stress-induced Cell Death
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Cellular Response To L-glutamate
Cellular Response To Glycine
Positive Regulation Of Protein Localization To Membrane
Regulation Of Calcium Ion Import Across Plasma Membrane
Positive Regulation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Angiogenesis
Lymph Vessel Development
Positive Regulation Of Receptor Internalization
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Macrophage Activation Involved In Immune Response
Neutrophil Activation Involved In Immune Response
Leukocyte Activation Involved In Immune Response
Serotonin Secretion By Platelet
Protein Phosphorylation
Protein Import Into Nucleus
Leukocyte Cell-cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Activation Of JUN Kinase Activity
Animal Organ Morphogenesis
Regulation Of Platelet Activation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Leukotriene Biosynthetic Process
Cell Differentiation
Platelet Activation
Neutrophil Chemotaxis
Positive Regulation Of Protein-containing Complex Assembly
Receptor Internalization
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-3 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Superoxide Anion Generation
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Cell Adhesion Mediated By Integrin
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Interleukin-2-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Mast Cell Degranulation
Regulation Of Neutrophil Degranulation
Beta Selection
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Bone Resorption
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Blood Vessel Morphogenesis
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Phagocytosis
Positive Regulation Of Calcium-mediated Signaling
B Cell Receptor Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Killing Of Cells Of Other Organism
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Molecule Of Fungal Origin
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Arachidonic Acid Secretion
Regulation Of Platelet Aggregation
Positive Regulation Of Cold-induced Thermogenesis
Pathways
GPVI-mediated activation cascade
Signaling by ERBB2
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Nephrin family interactions
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Platelet Adhesion to exposed collagen
Reelin signalling pathway
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
GPVI-mediated activation cascade
GPVI-mediated activation cascade
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Integrin signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Dectin-2 family
Interleukin-2 signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Dasatinib
Triglyme
Fostamatinib
Staurosporine
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide
Tamatinib
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
Ellagic acid
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Anger (
24489884
)
Autoimmune thyroid disease (
32581359
)
Bipolar disorder (
31043756
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
23128233
)
Intraocular pressure (
29617998
)
Macular thickness (
30535121
)
NASH resolution in nonalcoholic steatohepatitis (
31832568
)
Parkinson's disease (
32201043
32310270
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Schizophrenia (
28991256
30285260
)
Systolic blood pressure (
30578418
)
Ulcerative colitis (
28067908
)
Alzheimer's disease (
30636644
)
Anti-saccade response (
29064472
)
Atrial fibrillation (
28416822
)
Chromosomal aberration frequency (total) (
31586183
)
Frontal pole volume (
31530798
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Multiple sclerosis (
21833088
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Type 2 diabetes (
22456796
)
Vascular dementia (
23480133
)
Interacting Genes
198 interacting genes:
ACP1
ADAM15
ADD2
ARHGAP32
ARHGAP33
ATXN1
BAG4
BCAR1
BCL3
BTK
C7orf25
C8orf33
CASP3
CASP8
CAV1
CBL
CBLB
CBLC
CD19
CD2
CD226
CD247
CD2AP
CD36
CD44
CD48
CD5
CD55
CD79A
CD79B
CDH1
CDK1
CDK5
CLTC
CMA1
CNN1
CNN3
CNTN1
CNTNAP1
CRK
CSF1R
CSF2RB
CSK
CTLA4
CTNNB1
CTNND2
DAG1
DLG4
DLGAP4
DOK1
DOK3
DOK4
DTX3
EFS
ENO1
EPHA3
EPHA4
EPHA8
EPHB3
ERRFI1
EVL
FAM90A1
FAS
FASLG
FCER2
FCGR2A
FLOT1
FLOT2
FLT1
FNBP4
FYB1
GAB3
GP6
GRAP
GRB10
GRB2
GRIN1
GRIN2A
GRIN2B
HNRNPK
HRAS
HSP90AA1
HTR6
IGHA1
IL1B
IL2RB
IL7R
IRS1
ITCH
ITGB4
ITK
ITPR1
JAK2
JUP
KDM1A
KDR
KHDRBS1
KIT
LAT
LCK
LCP2
MAG
MAP2
MAPT
MCAM
MED28
MEOX2
MS4A1
NCAM1
NEDD4
NEDD9
NMT1
NOS1AP
NPHS1
NR3C1
NTRK2
PAG1
PAK2
PDE4D
PDGFRB
PECAM1
PIK3R1
PIK3R2
PIK3R3
PLAUR
PLCG1
PLCG2
PLD2
PRKCD
PRKCE
PRKCH
PRKCQ
PRKCZ
PRMT6
PRMT8
PTK2
PTK2B
PTPN11
PTPN5
PTPRA
PTPRC
PTPRE
PTPRF
PTPRZ1
PXN
RACK1
RAF1
RPL10
RPS6KA3
RPS6KB2
SDC3
SH2B2
SH2D1A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SLAMF1
SNCA
SOCS1
SOS1
SPHK1
SPHK2
SPN
STAT1
STAT3
SUV39H1
SYK
TAMALIN
TCAP
THY1
TNF
TNK2
TNNT1
TOM1L1
TRAF6
TRAT1
TRIM55
TRIM63
TRPC6
TRPV4
TUBA1B
TUBA3C
TUBA4A
TXK
TYK2
TYRO3
UHRF2
UNC119
VAV1
VAV2
WAS
WASF1
WASF2
WBP11
YTHDC1
ZAP70
107 interacting genes:
APP
AR
BLNK
BTK
CALM1
CBL
CBLB
CD19
CD22
CD3E
CD72
CD79A
CD79B
COASY
CRKL
CSF2RB
CSF3R
CTTN
DBNL
DPP9
DUSP3
EGFR
EPOR
ERBB2
ERBB3
ERBB4
FCER1G
FCGR1A
FCGR2A
FCGR3A
FCRL3
FGR
FYN
GAB1
GAB2
GRB2
HCLS1
HDAC1
HDAC2
HDAC3
HDAC4
HDAC6
HDAC9
HGS
HNRNPU
IL15RA
IL2RB
ITGB2
JAK1
KIT
LAT
LAX1
LCK
LCP2
LYN
MAP4K1
MAPK3
MAPT
MET
MS4A2
NEDD4
NFAM1
PAG1
PIK3AP1
PIK3R1
PIK3R2
PLCG1
PLCG2
POU2AF1
PRKCA
PRKD1
PTK2
PTK2B
PTPN6
PXN
RASA1
RHOU
RPS10
RPS6KA1
RPS6KB1
RPS6KB2
SELPLG
SH2B2
SH2D2A
SH3BP2
SHC1
SIT1
SLA
SLC4A1
SNCA
SRC
STAT1
STAT3
STAT5A
TERF1
TLR4
TNFRSF1A
TRAF6
TRIM15
TUBA1A
TUBA4A
TYROBP
UBASH3B
UBB
USP25
VAV1
VAV2
Entrez ID
2534
6850
HPRD ID
00655
02514
Ensembl ID
ENSG00000010810
ENSG00000165025
Uniprot IDs
P06241
A0A024R244
A0A024R273
P43405
PDB IDs
1A0N
1AOT
1AOU
1AVZ
1AZG
1EFN
1FYN
1G83
1M27
1NYF
1NYG
1SHF
1ZBJ
2DQ7
2MQI
2MRJ
2MRK
3H0F
3H0H
3H0I
3UA6
3UA7
4D8D
4EIK
4U17
4U1P
4ZNX
5ZAU
6EDF
6IPY
6IPZ
1A81
1CSY
1CSZ
1XBA
1XBB
1XBC
3BUW
3EMG
3FQE
3FQH
3FQS
3SRV
3TUB
3TUC
3TUD
3VF8
3VF9
4DFL
4DFN
4F4P
4FL1
4FL2
4FL3
4FYN
4FYO
4FZ6
4FZ7
4GFG
4I0R
4I0S
4I0T
4PUZ
4PV0
4PX6
4RSS
4RX7
4RX8
4RX9
4WNM
4XG2
4XG3
4XG4
4XG6
4XG7
4XG8
4XG9
4YJO
4YJP
4YJQ
4YJR
4YJS
4YJT
4YJU
4YJV
5C26
5C27
5CXH
5CXZ
5CY3
5GHV
5LMA
5LMB
5T68
5TIU
5TR6
5TT7
5Y5T
5Y5U
6HM6
6HM7
6SSB
6VOV
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?