FYN and PAK2

Data Source:
HPRD (in vitro)

		FYN	PAK2
Description		FYN proto-oncogene, Src family tyrosine kinase	p21 (RAC1) activated kinase 2
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GO Annotations	Cellular Component	Nucleus Mitochondrion Endosome Cytosol Actin Filament Plasma Membrane Postsynaptic Density Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Alpha-tubulin Binding Phosphatidylinositol 3-kinase Binding Ion Channel Binding Metal Ion Binding Ephrin Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Peptide Hormone Receptor Binding Growth Factor Receptor Binding Disordered Domain Specific Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MAPK Cascade Response To Singlet Oxygen Neuron Migration Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Heart Process Protein Phosphorylation Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Blood Coagulation Learning Feeding Behavior Regulation Of Cell Shape Negative Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Activation Forebrain Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Protein Catabolic Process Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Hydrogen Peroxide Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Ethanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Defense Response To Virus By Virus Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Leukocyte Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Protein Kinase B Signaling Cellular Response To Peptide Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Nucleus Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Death Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Response To Amyloid-beta Cellular Response To Amyloid-beta Cellular Response To L-glutamate Cellular Response To Glycine Positive Regulation Of Protein Localization To Membrane Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Phosphorylation Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Adherens Junction Assembly Interleukin-12-mediated Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Dendritic Spine Development Positive Regulation Of Protein Tyrosine Kinase Activity Bicellular Tight Junction Assembly Cellular Response To Organic Cyclic Compound Protein Localization To Cell-cell Junction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		GPVI-mediated activation cascade Signaling by ERBB2 PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling VEGFA-VEGFR2 Pathway Dectin-2 family CD209 (DC-SIGN) signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Platelet Adhesion to exposed collagen Reelin signalling pathway Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Dasatinib Triglyme Fostamatinib	Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anger ( 24489884) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Macular thickness ( 30535121) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Parkinson's disease ( 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 30285260) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908)	Asthma ( 31959851) Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Glucose homeostasis traits ( 25524916) Lymphocyte counts ( 32888494 27863252) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) White blood cell count ( 32888494 27863252)
Interacting Genes		198 interacting genes: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BAG4 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DLGAP4 DOK1 DOK3 DOK4 DTX3 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 ERRFI1 EVL FAM90A1 FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB1 GAB3 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B HNRNPK HRAS HSP90AA1 HTR6 IGHA1 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCK LCP2 MAG MAP2 MAPT MCAM MED28 MEOX2 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NOS1AP NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PRMT8 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RACK1 RAF1 RPL10 RPS6KA3 RPS6KB2 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TAMALIN TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRIM55 TRIM63 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70	54 interacting genes: ABI1 ABI2 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 H4C6 HCK LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NCK2 NPHP1 PACSIN3 PPM1A RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1
Entrez ID		2534	5062
HPRD ID		00655	05428
Ensembl ID		ENSG00000010810	ENSG00000180370
Uniprot IDs		P06241	A8K5M4 Q13177
PDB IDs		1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 2MQI 2MRJ 2MRK 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P 4ZNX 5ZAU 6EDF 6IPY 6IPZ	3PCS
Enriched GO Terms of Interacting Partners?
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