WWC1 and FEZ1

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		WWC1	FEZ1
Description		WW and C2 domain containing 1	fasciculation and elongation protein zeta 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ruffle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Microtubule Plasma Membrane Axon Dendrite Growth Cone Neuronal Cell Body
	Molecular Function	Transcription Coactivator Activity Protein Binding Kinase Binding Molecular Adaptor Activity	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Of Notch Receptor Target Cell Migration Establishment Of Cell Polarity Regulation Of Intracellular Transport Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of Organ Growth	Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Hippocampus Development Establishment Of Cell Polarity Positive Regulation Of Neuron Differentiation Establishment Of Mitochondrion Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Mitochondrion Morphogenesis Cellular Response To Growth Factor Stimulus Negative Regulation Of Autophagosome Assembly
Pathways		Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Adult body size ( 32376654) Cerebellum cortex volume ( 31530798) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epithelial ovarian cancer ( 31469419) Mental health study participation (provided email address) ( 31263887) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Periodontal microbiota ( 22699663) Regular attendance at a religious group ( 29970889) Type 2 diabetes nephropathy including microalbuminuria ( 30566433)	Breast cancer (survival) ( 25890600) Schizophrenia ( 22688191 23894747)
Interacting Genes		15 interacting genes: AIFM1 CDC5L CDC73 DDN FAM219A FEZ1 FEZ2 H3C1 KIAA0513 LRIF1 MAPK6 PRKCZ TNIK WWC2 WWC3	57 interacting genes: BARD1 BORA BRD1 C8orf33 CCL7 CEP126 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PPP4R3B PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 STAR TAC3 TAF1D TAF9 TBC1D25 TEDC2 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		23286	9638
HPRD ID		10033	09212
Ensembl ID		ENSG00000113645	ENSG00000149557
Uniprot IDs		Q8IX03	Q99689
PDB IDs		2Z0U 6FB4 6FD0 6FJC 6FJD
Enriched GO Terms of Interacting Partners?
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