FEZ1 and DIS3L2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FEZ1	DIS3L2
Description		fasciculation and elongation protein zeta 1	DIS3 like 3'-5' exoribonuclease 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Microtubule Plasma Membrane Axon Dendrite Growth Cone Neuronal Cell Body	Exosome (RNase Complex) P-body Cytoplasm Polysome
	Molecular Function	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding	3'-5'-exoribonuclease Activity Magnesium Ion Binding Ribonuclease Activity Protein Binding Poly(U) RNA Binding
	Biological Process	Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Hippocampus Development Establishment Of Cell Polarity Positive Regulation Of Neuron Differentiation Establishment Of Mitochondrion Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Mitochondrion Morphogenesis Cellular Response To Growth Factor Stimulus Negative Regulation Of Autophagosome Assembly	Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Catabolic Process Negative Regulation Of Cell Population Proliferation MiRNA Catabolic Process Stem Cell Population Maintenance Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Cell Division Mitotic Sister Chromatid Separation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Polyuridylation-dependent MRNA Catabolic Process
Pathways
Drugs
Diseases
GWAS		Breast cancer (survival) ( 25890600) Schizophrenia ( 22688191 23894747)	Chronic back pain ( 30261039) Height ( 28552196 25282103 25429064 23563607 31562340 19570815 18391951 20189936) Hip circumference adjusted for BMI ( 25673412) Refractive error ( 32231278) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		57 interacting genes: BARD1 BORA BRD1 C8orf33 CCL7 CEP126 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PPP4R3B PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 STAR TAC3 TAF1D TAF9 TBC1D25 TEDC2 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251	3 interacting genes: COPS6 FEZ1 VIM
Entrez ID		9638	129563
HPRD ID		09212	14619
Ensembl ID		ENSG00000149557	ENSG00000144535
Uniprot IDs		Q99689	Q8IYB7
PDB IDs
Enriched GO Terms of Interacting Partners?
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