WWC1 and WWC2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		WWC1	WWC2
Description		WW and C2 domain containing 1	WW and C2 domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ruffle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding Kinase Binding Molecular Adaptor Activity	Kinase Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Of Notch Receptor Target Cell Migration Establishment Of Cell Polarity Regulation Of Intracellular Transport Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of Organ Growth	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hippo Signaling Negative Regulation Of Organ Growth
Pathways		Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Adult body size ( 32376654) Cerebellum cortex volume ( 31530798) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epithelial ovarian cancer ( 31469419) Mental health study participation (provided email address) ( 31263887) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Periodontal microbiota ( 22699663) Regular attendance at a religious group ( 29970889) Type 2 diabetes nephropathy including microalbuminuria ( 30566433)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Heel bone mineral density ( 30598549) Height ( 28552196 20881960) Initial alcohol sensitivity ( 30276832)
Interacting Genes		15 interacting genes: AIFM1 CDC5L CDC73 DDN FAM219A FEZ1 FEZ2 H3C1 KIAA0513 LRIF1 MAPK6 PRKCZ TNIK WWC2 WWC3	4 interacting genes: REPS1 WWC1 WWC3 YWHAQ
Entrez ID		23286	80014
HPRD ID		10033	12529
Ensembl ID		ENSG00000113645	ENSG00000151718
Uniprot IDs		Q8IX03	Q6AWC2
PDB IDs		2Z0U 6FB4 6FD0 6FJC 6FJD
Enriched GO Terms of Interacting Partners?
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