WWC1 and CDC73

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WWC1	CDC73
Description		WW and C2 domain containing 1	cell division cycle 73
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ruffle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Kinase Binding Molecular Adaptor Activity	RNA Polymerase II Complex Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Of Notch Receptor Target Cell Migration Establishment Of Cell Polarity Regulation Of Intracellular Transport Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of Organ Growth	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Population Proliferation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Beta-catenin-TCF Complex Assembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases			Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Adult body size ( 32376654) Cerebellum cortex volume ( 31530798) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epithelial ovarian cancer ( 31469419) Mental health study participation (provided email address) ( 31263887) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Periodontal microbiota ( 22699663) Regular attendance at a religious group ( 29970889) Type 2 diabetes nephropathy including microalbuminuria ( 30566433)	Chronotype ( 30696823) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)
Interacting Genes		15 interacting genes: AIFM1 CDC5L CDC73 DDN FAM219A FEZ1 FEZ2 H3C1 KIAA0513 LRIF1 MAPK6 PRKCZ TNIK WWC2 WWC3	35 interacting genes: ALAS1 ANXA6 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 VPS37B WWC1
Entrez ID		23286	79577
HPRD ID		10033	09581
Ensembl ID		ENSG00000113645	ENSG00000134371
Uniprot IDs		Q8IX03	Q6P1J9
PDB IDs		2Z0U 6FB4 6FD0 6FJC 6FJD	5YDE 5YDF 6TED
Enriched GO Terms of Interacting Partners?
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